例外的是，这些药物也有临床明显的药物副作用——贝伐单抗可致高血压，吉非替尼和厄洛替尼可有皮肤毒性。
Fortuitously, these drugs also have clinically obvious pharmacodynamic end points-hypertension for bevacizumab and skin toxicity for erlotinib and gefitinib.
由于腹泻和皮肤毒性限制了此类药物的应用，研究人员期望发现ABCG2基因特异性的突变从而能够阻断ABCG2蛋白的功能。
Since diarrhea and skin toxicity limit the use of this drug in some patients, the researchers looked for a specific variation in the ABCG2 gene that could disrupt the function of the ABCG2 protein.
由于腹泻和皮肤毒性限制了此类药物的应用，研究人员期望发现ABCG2基因特异性的突变从而能够阻断ABCG2蛋白的功能。
Since diarrhea and skin toxicity limit the use of this drug in some patients, the researchers looked for a specific variation in the ABCG2 gene that could disrupt the function of the ABCG2 protein.
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