我认为这也是一个需要我们高度关注的大问题。
I think this is also a big problem which needs our great attention.
我感到每一个地方都隐藏着这种神秘。每天，我心里产生的最大问题是：什么时候，啊！
Something undreamt of was lurking everywhere and the uppermost question every day was: when, Oh! When would we come across it?
但是，带着信用危机给以前看似安全的有价证券造成的疑虑，对多数投资人而言，‘我的货币基金安全吗？’成了大问题。
But with the credit crunch casting doubt on many formerly safe-seeming securities, the big question for many investors has become, Is my money fund safe?
虽然不算什么大问题，我发现打气筒的一个零件掉在自比利时泽布鲁日出发以来的路上。
Hardly a major problem though, unless, that is, it then turns out that part of your bicycle pump has gone missing somewhere along the way from Zeebrugge.
在字节码生成的一般性问题方面，我列出了一个大问题：需要确保正在生成的代码符合JVM规范。
In the category of general problems with bytecode generation, I'd list one big issue: the need to make sure that the code you're generating is going to be valid according to the JVM specification.
我相信，金融救助方案的一大问题就是要察觉不该得的得到帮助，而该得的却被迫偿贷。
I believe that one of the big problems with the financial bail-out package is the perception that the undeserving got help, while the deserving were left to pay the bills.
她说上帝还不想抛弃我，不会有什么大问题。
She said that God was not through with me yet; there was no way that this was going to be a major problem.
一位男士曾坦白地说；“一个我无法回答的大问题是：女士想要的是什么？ ”？
Once a man confessed, "The great question I have not been able to answer is What does a woman want?"
我知道你应经通过了六级考试所以托福应该不是个大问题。
I know you've past the CET brand 6 so TOEFL won't be a big problem.
这让我想到Windows8存在的第二个大问题——Windows 8会毁掉如今主宰台式机和笔记本的Windows的核心。
That leads me to the second big issue with Windows 8 - it just might ruin the core Windows product that powers most of today's laptops and desktops.
但是，因为堆积成山的现金，我把这个时刻看作是一个获得伟大的人民和大问题的机会。
But with mountains of cash, access to great people and big problems, I see the moment as an opportunity.
事实上，这一事件已经变成一个大问题，我认为这件事表明一个事实，即种族问题仍然是困扰我们社会的一个方面。
The fact that this has become such a big issue I think is indicative of the fact that race is still a troubling aspect of our society.
如果说我作为一个私人教练这么多年学到了什么的话，那就是我发现，正确的节食是每个希望得到好身材的人所面临的最大问题。
If there is anything I have learned through my years as a personal trainer is that dieting right is the number one obstacle people face while trying to get fit.
在这里是个大问题，我在印尼倒是遇到一个有趣的故事，在印尼所有的学校里在操场上通常有一个卖玩具的人。
But there was one interesting anecdote that I found in Indonesia. In all schools in Indonesia, there is usually a toy seller in the playground.
可事实却不是这样：通常情况下，当遇到我们一生中的重大问题时，比如——我是否应当接受这份工作？
The truth is that quite often, when it comes to the big questions in our lives — Should I take the job?
在英国，我一直和那些流浪汉交流，向他们推销《大问题》——事实上这并不花费巨大，也不需要花费你日常生活的很多时间，只是需要进行正常的谈话而已。
Here in London, I always chat to a homeless person selling The Big Issue - it really doesn't take much to take some time out of your routine and just have a normal conversation.
以往，我也曾在一些重大问题上改变自己的观点。
In the past I've changed my opinions on some important issues.
我认为这是接下来要解决的一大问题，具有社会责任感的公司必须解决好供应链中被贩卖的工人问题。
I see it as the next big issue that socially responsible companies are going to have to deal with — the amount of trafficked workers in their supply chains.
我将这些邮件过滤到一个每夜查看的文件夹，但如果我无法在夜间查看，也不是什么大问题。
I filter these into a folder that I try to review nightly - but if I can't get to it nightly, no big deal.
我作为主持人的最大问题是从同伴分享的角色中回到整个团队中。
My biggest problem as a facilitator was transitioning from the share pair back to full group.
我将以两大问题为重点：首先，涉及关塔纳摩监狱和我们的关押政策的问题；其次，涉及安全与透明度的问题。
And I will focus on two broad areas: first, issues relating to guantanamo and our detention policy; second, issues relating to security and transparency.
一直以来我都想要一个自己的孩子，但我知道我的先天条件是个大问题。
I'd always dreamed of having a child but knew my restricted growth might be an issue.
我们有重大问题得解决，我相信我们能够解决这些问题。
We have got big problems to solve, and I am confident that we can solve them.
对于我来说这样没多大问题，因为我一直都在练习举重，跑步和打篮球，并且70%的时间都是在吃健康食品。
For me this is fine because I am lifting weight, running, and playing basketball and eating healthy 70 percent of the week.
我认为我们面临的最大问题是如何使其保持在预算之内。
I think the biggest problem we're facing is how to bring it in under budget.
但是在强调了检验出阳性反应的人后，我还要说的是：艾滋病毒仍然是这个国家的巨大问题。
But having stressed the positives I also want to say that HIV remains a massive challenge for this country, "he said."
伴随大量藏书而来的最大问题就在于我有时会忘记哪些书我已经有了。
The biggest problem with having a large collection of books is that I'll sometimes forget which books I already have.
但是历史在呼唤，我突然想到如果不采取行动，后果是严重的，这就决定了国会展示解决现代重大问题的能力的紧迫性。
But when history calls, history calls and I happen to think that the consequences of inaction dictate the urgency of Congress to demonstrate its capacity to solve the monumental issues of our time.
但是历史在呼唤，我突然想到如果不采取行动，后果是严重的，这就决定了国会展示解决现代重大问题的能力的紧迫性。
But when history calls, history calls and I happen to think that the consequences of inaction dictate the urgency of Congress to demonstrate its capacity to solve the monumental issues of our time.
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