目的:研究大黄酸对系膜细胞萄萄糖摄入的影响,探讨大黄酸拮抗糖尿病肾脏代谢异常的可能机制。
OBJECTIVE To explore the effect of rhein on glucose uptake in mesangial cells and the possible molecular mechanism.
目的研究反义单核细胞趋化蛋白1 (MCP - 1)对系膜细胞MCP - 1分泌及增生的影响。
Objective To examine the influence of antisense MCP-1 on MCP-1 production and mesangial cell proliferation.
目的:研究极低密度脂蛋白对SD大鼠系膜细胞的促增殖作用。
Objective: To study the proliferation promotion effect of very low density lipoprotein on mesangial cells of SD rats.
目的研究氯通道阻滞剂对肾小球系膜细胞增殖的作用。
Aim To investigate effects of chloride channel blockers on proliferation of mesangial cells.
目的:探讨中药肾康注射液对脂多糖诱导肾小球系膜细胞增殖的影响。
Objective: To study the effect of Shenkang injection on the proliferation of human mesangial cell induced by LPS.
目的探讨醛固酮对大鼠肾小球系膜细胞结缔组织生长因子基因表达的影响。
To evaluate the effect of aldosterone on connective tissue growth factor mRNA expression in cultured rat mesangial cells.
目的探讨人肾小球系膜细胞脂蛋白脂酶(LPL)的表达情况以及极低密度脂蛋白(VLDL)对其表达的影响。
Objective To study the expression of lipoprotein lipase(LPL) in human glomerular mesangial cells and the effect of very low-density lipoprotein(VLDL) on the expression of LPL.
目的:探讨血小板活化因子(PAF)对肾小球系膜细胞(GMC)合成前列腺素e2 (PGE2)的影响及其意义。
OBJECTIVE to explore the effect and significance of platelet activating factor (PAF) on prostaglandin E2 (PGE2) synthesis in rat glomerular mesangial cell (GMC) in culture.
目的:探讨温脾汤药物血清对原代培养大鼠系膜细胞增殖的影响。
Objective:To study the effect of Wenpitang pharmacologic serum on proliferation of mesangial cells of rats in vitro.
目的:探讨缬沙坦和低分子量肝素对高糖刺激大鼠系膜细胞增殖的影响。
Objective: To observe the effect of valsartan and low molecular weight heparin on the proliferation of glomeruli mesangial cells stimulated by high glucose.
目的:探讨肾康注射液与苯那普利对人肾小球系膜细胞(MC)增殖的不同抑制作用强度。
To explore the intensity of inhibitory function of Shenkang injection (SKI), a Chinese herbal recipe, and benazepril on the proliferation of human glomerular mesangial cell (MC).
目的:研究高糖对正常人类系膜细胞(NHMC)增殖及金属蛋白酶2(MMP2)和金属蛋白酶9(MMP9)表达的影响及肝素对其的干预作用。
Objective: To investigate the effects of high glucose and heparin on the proliferation and expression of MMP2, MMP9 in normal human mesangial cells (NHMC).
目的观察缓激肽(BK)对高糖浓度下肾小球系膜细胞增殖和细胞外基质分泌的影响。
Objective To observe the effect of bradykinin(BK) on kidney mesangial cell multiplication and extracellular matrix secretion under high glucose environment.
目的研究醛固酮(ald)及其受体拮抗剂螺内酯(SPI)对大鼠肾小球系膜细胞增殖和细胞周期的影响。
Aim to evaluate the effects of aldosterone (ald) and spironolactone (spi, one of the aldosterone receptor antagonists) on proliferation and cell cycle phase of cultured rat mesangial cells in vitro.
目的:探讨尼卡地平对大鼠肾小球系膜细胞凋亡的影响及其分子机理。
Objective:To explore the effects of nicardipine on apoptosis of rat mesangial cells and its molecular mechanisms.
提示,临床上LMWH能通过对增生性肾炎患者系膜细胞增殖和系膜基质积聚的抑制作用而发挥效应。
The effect of LMWH on patients with proliferative glomerulonephritis may be associated with inhibiting the proliferation of mesangial cell and the accumulation of mesangial matrix.
目的探讨“延肾胶囊”对残肾肾小球系膜细胞凋亡及其细胞外基质代谢的影响。
Objective To elucidate the effect of Yan-Shen Capsule on glomerular mesangial cell apoptosis and extracellular matrix metabolism of remnant kidney.
目的:研究高糖对人肾小球系膜细胞丝裂原蛋白激酶(MAPK)活性的影响,探讨其在糖尿病肾病发病中的作用。
Objective To study the effects of high glucose on activity of mitogen activated protein kinase (MAPK) in cultured human mesangial cells and to explain the mechanism of diabetic nephropathy.
结论:HGF通过促进系膜细胞表达LDL受体,增加系膜细胞对LDL的摄取,可能参与了脂质肾损伤过程。
Conclusion: HGF can up-regulate expression of LDL receptor in mesangial cells and increase mesangial cells uptake of LDL, so HGF may play a role in lipid-induced kidney injury.
目的研究血小板源生长因子(PDGF)对肾小球系膜细胞(MC)表型转化的影响,并探讨丝裂素活化蛋白激酶(MAPK)信号转导途径在其作用中的调控机制。
Objective to investigate effects of PDGF on phenotypic change of glomerular mesangial cells (MC), and study intracellular mechanisms through mitogen-activated - protein kinase (MAPK) pathways.
肾小球系膜细胞(GMC)的增殖通过影响细胞外基质(ecm)的分泌和对肾小球毛细血管的机械损伤而在肾小球硬化过程中发挥着重要作用。
BackgroundThe GMC proliferation plays an important role in glomerular sclerosis by influencing the ECMs secretion and mechanical injury on the glomerular capillaries.
利用MTT法检测多糖对大鼠肾系膜细胞增殖的影响。
MTT assay was used to study the effect of polysaccharides on rat glomerular mesangial cells.
方法:采用MTT比色法,观察缬沙坦和低分子量肝素不同作用时间和不同作用浓度以及二者合用时对高糖刺激系膜细胞增殖的影响。
Methods:The mesangial cell line was treated by valsartan and low molecular weight heparin under different concentrations and times, and the proliferation activity was measured by MTT.
方法:采用MTT比色法,观察缬沙坦和低分子量肝素不同作用时间和不同作用浓度以及二者合用时对高糖刺激系膜细胞增殖的影响。
Methods:The mesangial cell line was treated by valsartan and low molecular weight heparin under different concentrations and times, and the proliferation activity was measured by MTT.
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