目的介绍在遗传流行病学病例对照研究中，应用多因子降维法（MDR）分析基因-基因交互作用。
Objective To introduce the application of Multifactor Dimensionality Reduction (MDR) method for detecting gene-gene interactions in genetic case-control studies.
数年前，他提炼出一种技术，可以将基因网络“毛团”——对基因交互作用密集纠结的描绘——转化成分层图。
Several years ago, he refined a technique for turning gene-network "hairballs" - densely tangled depictions of gene interaction - into hierarchical maps.
这类电路的一个潜在的强大应用是：用于遗传网络建模——基因和蛋白质的交互作用控制着细胞的功能和命运。
One potentially powerful application of such circuits is in modeling genetic network — the interplay of genes and proteins that controls a cell's function and fate.
结论ALDH2基因多态性与胃癌易感性有关，并与环境暴露有一定的交互作用。
Conclusion The genetic polymorphisms of ALDH2 might contribute to gastric cancer susceptibility and interact with environmental exposure.
方法以评价基因-环境交互作用的乳腺癌病因学研究为实例，介绍反向配比的设计方法和统计分析方法。
Methods Through elaboration of the study about gene-environment interactions in the etiology of breast cancer, methodology regarding counter-matching design and statistic methods was introduced.
广义线性模型分析提示CXCR4和CCR3基因与环境交互作用与SLE的发病不存在关联。
Result of generalized linear model showed that interaction between CXCR4 and CCR3 gene and environmental was irrelevant to pathogenic of SLE.
结论叉生分析在基因环境交互作用分析中可进一步应用。
Conclusion Crossover analysis should further be applied in gene-environmental interaction studies.
目前研究普遍认为膀胱癌是受环境暴露、个体遗传背景及基因环境交互作用影响的多因素疾病。
Bladder cancer is considered a multifactorial disease where multiple exposures interact with the individual genetic background resulting in risk modulation.
目的探讨叉生分析在基因环境交互作用研究中的作用和意义。
Objective To examine the significance of crossover analysis in gene-environmental interaction studies.
本研究的目的在于进一步证实BRD7蛋白与BRD2、BRD3蛋白之间的交互作用，探讨BRD2、BRD3基因在鼻咽癌中的表达和作用模式。
This study was designed to further identify the interactions of BRD2 and BRD3 with BRD7 respectively and to investigate the expression and action pattern of BRD2 and BRD3 in NPC.
目的介绍不完全病例对照研究中基因与环境交互作用的估计方法。
Objective To introduce the approaches for estimating gene-environment interaction based on partial case-control studies.
方法用PCR-RFLP技术分析了原发性肺癌组和住院对照组（各163例）的CYP1A1、GSTM1基因的多态性、基因型分布频率和交互作用。
Methods CYP1A1 and GSTM1 genetic polymorphisms were determined by PCR-RFLP in 163 lung cancer cases and healthy controls respectively.
结果对基因环境交互作用的分析依赖于相加或相乘模型的选择。
Results Different models (additive or multiplicative) in analyzing gene-environmental interaction yielded different results.
对于基因数据，则采用回归树分析基因与基因之间、基因与环境之间的交互作用。
For analysis of genomic data, regression tree approaches to the analysis of interactions between genes and between genes and the environment will be used.
毒理基因组学主要在基因组水平上研究机体对环境因子的应答反应，了解基因和环境交互作用在疾病发生中的作用。
Toxicogenomics mainly study the response of human body to the environmental elements, and understand the effect of gene-environment interaction to the disease in molecular level.
用五种遗传稳定型分析方法对四个区域化试验点的5个美洲黑杨无性系生长量的基因型与环境交互作用进行了分析。
The genotype-environment interaction of 4-year DBH growth was analyzed in 4 locations for 5 cottonwood clones by using 5 genetic stability analysis methods.
吸烟、饮酒与胃癌易感性增加有关，GSTM1和GSTT1基因型及烟酒嗜好在胃癌发生中存在一定的交互作用。
Smoking and drinking habit are likely associated with the susceptibility to gastric cancer; interaction of GSTM1, GSTT1 genotype and smoking, alcohol drinking exists in the risk of gastric cancer.
目的：研究银屑病hla - A 2 6等位基因与环境危险因素之间的交互作用。
Objective: to study the interaction between HLA-A26 allele and environmental risk factors in psoriasis.
目的：研究银屑病hla - A 2 6等位基因与环境危险因素之间的交互作用。
Objective: to study the interaction between HLA-A26 allele and environmental risk factors in psoriasis.
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