目的观察盐酸格拉司琼止吐效果和毒性。
Objective To study the antiemetic effect and toxicity of granisetron.
目的合成盐酸帕洛诺司琼。
目的合成盐酸托烷司琼并改进其合成工艺。
OBJECTIVE To synthesize Tropisetron hydrochloride and optimize the process.
结果合成了盐酸帕洛诺司琼，总收率76%。
RESULTS The total yield of palonosetron hydrochloride was 76%.
用紫外分光光度法测定主药昂丹司琼的含量。
The content of ondansetron in the sustained release tablets was determined by UV spectrophotometry.
对照组化疗期间常规应用格拉司琼药物治疗。
The patients in the control group were treated routinely with Granisetron Hydrocloride Injection during chemotherapy.
本发明的帕洛诺司琼注射液稳定性高，异构体减少。
The palonosetron injection has the advantages of high stability and less isomer.
结论使用昂丹司琼治疗急性酒精中毒呕吐效佳且安全。
Conclusion Its safe and good effects in treat vomiting patients with acute alcoholism by Ondansetron.
格拉司琼可作为预防化疗引起的恶心、呕吐的优选药物。
Granisetron is a good choice drug in the prevention of chemotherapy induced nausea and vomiting.
探讨格拉司琼用于恶性肿瘤患者化疗止吐的最佳用药时间。
To study the best time to inject granisetron as antiemetic for cancer chemotherapy.
结论：采用效应面法完成了盐酸昂丹司琼微球的多目标优化。
Conclusion: The multi-objective optimization of ondansetron hydrochloride PLGA microspheres formulation technique is obtained by response surface method.
目的探讨盐酸雷莫司琼注射液安全性，为临床用药提供参考。
Objective It's to provide reference for clinical utilization that the safety of ramosetron hydrochloride injection was studied.
以淀粉为主要填充剂，采用不同工艺制备盐酸托烷司琼胶囊。
The tropisetron hydrochloride capsules were prepared by different methods with starch as main excipient.
结论在恶性肿瘤化疗前30分钟应用格拉司琼止吐的效果最好。
Conclusion Application of granisetron 30 minutes before chemotherapy has the best antiemetic effect amongst three groups.
目的：探讨应用格拉司琼治疗妇科肿瘤化疗后恶心、呕吐的效果。
Objective: To study the efficacy of granisetron for treating nausea and vomiting after chemotherapy of gynecological tu-mors.
目的考察昂丹司琼注射液与注射用顺铂在氯化钠注射液中的稳定性。
Aim To study the compatibility after mixing ondansetron injection, cisplatin for injection, and sodium chloride injection.
结论盐酸托烷司琼氯化钠注射液治疗化疗药物所致恶心、呕吐安全有效。
Conclusion Tropisetron hydrochloride and sodium chloride injection is safe and effective on nausea and vomiting induced by chemotherapy.
目的：系统评价托烷司琼预防全麻术后恶心呕吐(PONV)的有效性。
Objective: to systematically evaluate the efficacy of tropisetron for postoperative nausea and vomiting (PONV).
目的探讨昂丹司琼在腹腔镜胆囊切除术(LC)后恶心、呕吐的防治作用。
Objective to discuss ondansetron on postoperative nausea and vomiting after laparoscopic cholecystectomy (LC).
结论：盐酸格拉司琼注射液是一种防治肿瘤化疗所致呕吐的安全、有效药物。
CONCLUSION: it suggested that domestic granisetron hydrochloride injection is a safe and effective drug in the prevent the vomiting induced by chemotherapy.
所述的止吐药剂为格拉司琼、昂丹司琼、托烷司琼、阿瑞匹坦或甲氧氯普胺。
The compound preparation is prepared from the rolipram and the granisetron, the ondansetron, the tropisetron, the aprepitant or the metoclopramide.
结果：托烷司琼组与恩丹西酮组止吐疗效比较有显著性差异（P<0.05）。
Results:The effective rate of Tropisetron group was significantly higher than that of the Ondansetron group (P<0.05).
目的：观察哌替啶、非那根、格拉司琼预防硬膜外麻醉期间寒战反应的临床表现。
Objective:To observe the effects of pethidine, phenergan and granisetron in the prevention of shivering during operation after epidural anesthesia.
目的：研究国产盐酸托烷司琼胶囊与进口注射液口服给药后的人体相对生物利用度。
OBJECTIVE To study the pharmacokinetics and relative bioavailability of tropisetron hydrochloride domestic capsule and imported injection in healthy volunteers.
目的观察甲基强的松龙联合格拉司琼预防治疗化疗药物所至的顽固性呕吐反应的疗效。
Objective This study observed the antiemetic efficacy of methylprednisolone combined with granisetron in the management of obstinate vomiting induced by chemotherapy.
目的制备盐酸昂丹司琼渗透泵型控释片剂(OND - OPT)并考察体外释药特性。
Aim To prepare ondansetron hydrochloride osmotic pump tablets (OND-OPT) and investigate their in vitro drug release behavior.
以3-吲哚甲酸为起始原料，经氯化亚砜酰氯化、与托品醇缩合合成了托烷司琼盐酸盐。
Tropisetron Hydrochloride was synthesized from 1Hindol-3-carboxylic acid by chloride acetylation and condensation with Tropic alcohol.
目的观察雷莫司琼预防术后患者自控静脉镇痛（PCIA）期间恶心呕吐的防治效果及安全性。
Objective To observe the efficacy and safety of ramosetron for preventing nausea and vomiting during postoperative patient controlled intravenous analgesia(PCIA).
临床研究部分是采用中药敷脐联合托烷司琼防治含顺铂化疗方案所致呕吐、食欲减退的临床观察。
Objective: To observe the effects of Tropisetron combined with herbs used externally in treatment of emesis and anorexia caused by cisplatin-based chemotherapy.
目的建立高灵敏度HPLC法测定血浆中昂丹司琼含量，并研究盐酸昂丹司琼口崩片的生物利用度。
Aim to develop a high resolution HPLC method for the determination of ondansetron in human plasma and to study the pharmacokinetics of ondansetron in orally disintegrating tablets.
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