肝星状细胞是一种与肝纤维化密切相关的主要的细胞种类，它在肝受到损伤时形成瘢痕组织。
HSCs are the major cell type involved in liver fibrosis, which is the formation of scar tissue in response to liver damage.
国际肝病：除了肝星状细胞在肝纤维化发生中的重要作用，还有哪些机制参与了肝纤维化的发生？
International Hepatology: Besides the important role of hepatic stellate cell in liver fibrosis development, are there any other important mechanisms involving liver fibrosis development?
请您给我们介绍一下抗肝纤维化药物对于肝星状细胞的可能的作用机制？
Would you please give us a brief introduction on the possible strategies to target HSCs using anti-fibrotic agents?
我们知道肝星状细胞还是纤维化过程中细胞外基质的主要来源。
We know that hepatic stellate cells are still the major source of extracellular matrix during fibrogenesis.
肝星状细胞的激活、表型改变并分泌大量的细胞外基质是肝纤维化发生的中心环节。
The activation of hepatic stellate cell phenotype change and secretion of extracellular matrix of liver fibrosis is the central link.
目的研究肝星状细胞(HSC)与肝纤维化和肝硬化的关系。
Objective To investigate the relationship between hepatic fibrosis and hepatic stellate cell (HSC).
目的：为深入探讨肝纤维化的细胞机制，探索经济、稳定的肝星状细胞分离和培养方法。
Objective: To investigate the method of isolation and culture of hepatic stellate cells for studying the cellular mechanisms of hepatic fibrosis.
控制肝星状细胞的激活和增殖并逆肝纤维化的进程是抗肝纤维化研究的重点之一。
The manipulation of the activation and proliferation of hepatic stellate cells and the process of liver fibrosis inversion are the key in anti-liver-fibrosis researches.
在过去20年中，我认为我们做了很好的工作，确立了星状细胞的重要性，明确了星状细胞激活是导致纤维化的原因。
I think we have done a very good job over the past 20 years of establishing the importance of stellate cells and stellate cell activation as the cause of fibrosis.
目的：在精密肝切片中利用乙醛激活肝星状细胞，建立一种星状细胞激活的体外模型，为研究和筛选阻抑肝纤维化发生的药物奠定基础。
AIM: To activate hepatic stellate cells (HSC) in vitro in precision-cut liver slices (PCLS) stimulated by acetaldehyde for studying and screening anti-fibrotic drugs.
肝组织中PAI - 1的表达与星状细胞活化有关，可反映肝纤维化的进展，但不能反映肝纤维化程度。
The expression of PAI-1 in liver tissue relates with activity HSCs. It reflects the development of liver fibrosis but not the degree.
CTGF的表达主要集中于汇管区和纤维化区，肝星状细胞、成纤维细胞和窦状隙内皮细胞染色常呈阳性。
CTGF was mainly expressed in portal tracts and fibrotic areas. Positive staining was observed in hepatic stellate cells, sinusoidal endothelial cells and fibroblasts.
胰腺纤维化是各类慢性胰腺炎的共同特征，胰腺星状细胞(PSC)在胰腺纤维化进程中起重要作用。
Progressive fibrosis is a characteristic feature of chronic pancreatitis, and pancreatic stellate cell plays an important role in the fibrotic progression of pancreas.
胰腺纤维化是各类慢性胰腺炎的共同特征，胰腺星状细胞(PSC)在胰腺纤维化进程中起重要作用。
Progressive fibrosis is a characteristic feature of chronic pancreatitis, and pancreatic stellate cell plays an important role in the fibrotic progression of pancreas.
应用推荐