目的制备盐酸丁咯地尔冻干注射剂。
Objective To prepare Buflomedil Hydrochloride for Injection.
目的探讨盐酸丁咯地尔治疗突发性聋的疗效。
AIM To explore the therapeutic effect of buflomedil hydrochloride injection on sudden deafness.
结果：盐酸丁咯地尔与有关物质间有良好分离。
Results: There was a good separation between buflomedil and every relative impurity.
目的观察丁咯地尔对豚鼠噪声性听力损伤的影响。
Objective To study the protective effect of Buflomedil on noise-induced hearing loss in guinea pigs.
目的观察盐酸丁咯地尔注射液治疗急性脑梗死的疗效。
Objective To investigate the therapeutic effect of Buflomedil Hydrochloride Injection on acute cerebral infarction.
目的应用定制设计法优化盐酸丁咯地尔缓释片的处方。
Objective To prepare and optimize the formulation of buflomedil hydrochloride sustained release tablets.
目的观察盐酸丁咯地尔治疗椎基底动脉供血不足临床疗效。
Objective To observe the clinical effect of hydrochloric buflomedil on vertebrobasilar ischemia.
方法采用高效液相色谱法测定丁咯地尔及有关物质的含量。
Methods The content and related substances in freeze-dried injection were determined by HPLC.
这是丁咯地尔注射制剂风险收益评估结果出来前的临时措施。
This is an interim recommendation pending the finalisation of the continuing review of the benefits and risks of buflomedil solution for injection.
目的研究丁咯地尔联合丹红注射液治疗急性脑梗死的临床疗效。
Objective To study the clinical effect of Buflomedil combined with Danhong Injection in treating patients with acute cerebral infarction.
结果：丁咯地尔组疗效较好，奥扎格雷组和低分子肝素钙组次之。
Result: The effect of buflomedil group was better than ozagrel group and low molecular heparin calcium group.
结果：盐酸丁咯地尔组给药4周后能显著改善大鼠坐骨神经损害。
Results:At the end of 4 weeks, Buflomedil Hydrochloride can obviously recover the sciatic crash lesion in rats.
目的：比较国产丁咯地尔与己酮可可碱治疗急性脑梗死的疗效及安全性。
Objective:To evaluate the therapeutic effect and safety rate of domestic buflomedil and trental in the treatment of acute cerebral infarction(ACI).
目的：评价康复新液联合盐酸丁咯地尔注射液治疗糖尿病足溃疡的临床疗效。
OBJECTIVE: To evaluate the clinical effect of Kangfuxin plus Buflomedil hydrochloride on diabetic ulcer foot.
丁咯地尔是一种血管活性物质，可用于外周动脉闭塞性疾病(POAD)的治疗。
Buflomedil, a vasoactive agent, is used to treat the symptoms of peripheral arterial occlusive disease (PAOD).
本发明的丁咯地尔的制备方法具有安全可靠，反应时间较短，并取得了理想的收率和产品纯度。
The preparation method for buflomedil of the invention has the advantages of safety, reliability, shorter reaction time, ideal yield and product purity.
目的：在严格的质量评价基础上，对丁咯地尔治疗急性脑梗死的临床疗效与安全性进行系统评价。
OBJECTIVE: on the basis of strict quality evaluation, clinical curative effect and the safety of buflomedil for the treatment of acute cerebral infarction (ACI) were made a system evaluation.
目的：研究大鼠坐骨神经损伤后背根神经元细胞色素C的表达及丁咯地尔预处理对其表达水平的影响。
Objective: To study the effects of buflomedil on the changes of cytochrome C expression in dorsal root ganglion neurons in rats of sciatic nerve lesion model.
结论预防性使用丁咯地尔可以减轻噪声对豚鼠耳蜗的损害，对噪声引起的听力损伤可能有一定的保护作用。
Conclusion Preventive use of Buflomedil could alleviate noise-induced damage to outer hair cells in guinea pigs, and could protect against noise-induced hearing loss to some extent.
在2011年2月法国药品管理机构做出吊销丁咯地尔销售许可决定后，CHMP开始了本次对丁咯地尔的评估工作。
The review of buflomedil was initiated following the decision of the French regulatory authority in February 2011 to suspend the marketing authorisation.
在2011年2月法国药品管理机构做出吊销丁咯地尔销售许可决定后，CHMP开始了本次对丁咯地尔的评估工作。
The review of buflomedil was initiated following the decision of the French regulatory authority in February 2011 to suspend the marketing authorisation.
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