Thirdly, they engineered mice to produce high levels of TSLP in their skin in the absence of other skin problems.
第三,他们设计让老鼠在它们没有其他皮肤问题的情况下,在它们的皮肤里产生高水平的胸腺基质淋巴细胞生成素。
Then they used additional engineering to delete the gene for the receptor molecule which picks up TSLP in the lungs.
接着,他们用另外的工程删除在肺部接收胸腺基质淋巴细胞生成素的感受器分子的基因。
The skin is effective at secreting TSLP into the blood system, and therefore the substance is transported around the body.
皮肤能有效分泌TSLP进入到血液系统里,因此这种物质被转运到皮肤周围。
Taken together these experiments indicate-at least in mice-that skin damage creates susceptibility to asthma by releasing TSLP.
所有的这些实验综合起来表明- - -至少在老鼠身上如此- - -受损皮肤通过释放TSLP从而导致易患哮喘病。
Additional experiments showed that mice that had normal skin but were engineered to overproduce TSLP also developed the asthma-like symptoms.
另外的试验表明,正常皮肤但设计过多产生TSLP的小鼠也会发生类似哮喘症状。
Thirdly, they engineered mice to produce high levels of TSLP in their skin in the absence of other skin problems. These mice also developed asthma。
再接下来,在没有其它皮肤病的情况下,他们利用基因工程技术让老鼠在皮肤中产生大量的TSLP,这些老鼠也患上了哮喘病。
In the longer term, it might be possible to devise drugs that inhibit the production of TSLP or interfere with TSLP-receptor molecules in the lungs.
在长时间里,可能发明出一种药物,就是能抑制胸腺基质淋巴细胞生成素的产物或者干扰肺部里的胸腺基质淋巴细胞生成素感受器分子。
The researchers found that cells in damaged skin can secrete TSLP (thymic stromal lymphopoietin), a compound capable of eliciting a powerful immune response.
研究者们发现受损皮肤细胞能分泌TSLP(胸腺间质的淋巴细胞生素),这是一种能引起强免疫应答的复合物。
This study was designed to examine the effects of inhaled budesonide on TSLP expression in the lung tissues and on the bronchial-pulmonary pathology in asthmatic rats.
本研究旨在观察布地奈德对哮喘大鼠肺部TSLP表达的影响及对支气管-肺组织病理的影响。
The culprit is thymic stromal lymphopoietin (TSLP), a signalling molecule secreted by damaged skin cells which elicits a strong immune response from the body to fight off invaders.
罪魁祸首就是胸腺基质淋巴生成素(简称TSLP),这是一种由受损的皮肤分泌的信号分子,受损的皮肤引起身体强烈的免疫反应以便对抗入侵细胞。
The culprit is thymic stromal lymphopoietin (TSLP), a signalling molecule secreted by damaged skin cells which elicits a strong immune response from the body to fight off invaders.
罪魁祸首就是胸腺基质淋巴生成素(简称TSLP),这是一种由受损的皮肤分泌的信号分子,受损的皮肤引起身体强烈的免疫反应以便对抗入侵细胞。
The culprit is thymic stromal lymphopoietin (TSLP), a signalling molecule secreted by damaged skin cells which elicits a strong immune response from the body to fight off invaders.
罪魁祸首就是胸腺基质淋巴生成素(简称TSLP),这是一种由受损的皮肤分泌的信号分子,受损的皮肤引起身体强烈的免疫反应以便对抗入侵细胞。
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