The expression of MMP 9 and TIMP 1 is relate to soft tissue invasion, directly or indirectly influencing the prognosis of patients with osteosarcoma.
TIMP 1的表达与骨肉瘤的软组织浸润有关，直接或间接影响患者的预后。
The objective is to observe the expression of MMP-1and TIMP-1 in nucleus pulposus cells of intervertebral disc degeneration.
目的是测定 MMP-1及TIMP-1在人退变椎间盘髓核中的表达。
Conclusion MMP-2, MMP-9 and TIMP-1 play an important role in the infiltrative metastasis of seminoma and may act as one of the factors to evaluate prognosis.
结论MMP - 2、MMP - 9、TIMP - 1在人睾丸精原细胞瘤的浸润转移过程中起重要作用，有可能成为估计预后的指标之一。
The function of TIMP-1 in cell cycle regulation was analyzed.
对TIMP - 1在细胞周期调控中的作用进行了分析。
Results (1) There were no significant negative relationships between MMP-1, TIMP-1 and BMD and bone biochemical markers.
结果（1）绝经后妇女血清MMP-1、TIMP-1水平与骨密度、骨转换生化指标无明显相关性。
Objective to study the expression of matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1) proteins in the decidua and villi of the early pregnancy.
目的研究基质金属蛋白酶- 9 (MMP - 9)和基质金属蛋白酶抑制物- 1 (TIMP - 1)在早孕期蜕膜和绒毛中的表达特点。
Results The results of immunohistochemistry and double immunofluorescence showed that TIMP-1 was positive in vascular endothelial cells of normal muscles.
结果免疫组织化学和双免疫荧光标记结果显示TIMP-1在正常肌肉的血管内皮细胞处表达；
To evaluate significance of serum levels of MMP-9 and TIMP-1 as serum target of plaque rupture.
评价血清mmp 9及TIMP 1水平作为粥样斑块破裂的血清学指标的意义。
Conclusion Rosiglitazone can adjust the mRNA expressions of MMP-1 and TIMP-1 and inhibit the cumulation of extracellular matrix in kidney fibroblasts induced by high glucose.
结论罗格列酮可以通过调节MMP - 1和TIMP - 1的基因表达，抑制高糖导致的肾脏成纤维细胞外基质的蓄积。
The nuclear distribution of TIMP-1 in liver cancer cells was observed.
首次发现TIMP-1在肝癌细胞中的核内分布现象。
The gene expression levels for interstitial collagenase and tissue inhibitor of metallo-proteinase-1 (TIMP-1) were measured by reverse transcription polymerase chain reaction.
逆转录多聚酶链反应检测间质胶原酶及金属蛋白酶组织抑制因子- 1基因表达水平。
Conclusion TIMP-1 expression increased in hepatic fibrosis. IL-10 exhibit an antifibrogenic effect by suppressingTIMP-1 expression.
结论TIMP 1随着大鼠肝纤维化进展表达逐渐升高，IL 10通过抑制TIMP 1的表达，起抗纤维化作用。
Conclusions The abnormal expressions of MMP? 1, 2, 3 and TIMP? 1, 2, which resulted in degradation disorder of extracellular matrix, could induce degeneration of cartilage.
结论在骨关节炎中MMP1、2、3和TIMP 1、2表达异常，引起细胞外基质异常降解，是导致关节软骨发生组织学退变的原因之一。
Conclusion the expression of TIMP-1, -2 in human dental pulp cell and tissue is detected, and this provides the basis for further studying on the mechanism of TIMP in dental pulp.
结论TIMP 1、2在人牙髓成纤维细胞及牙髓组织均有表达，为进一步研究TIMP在牙髓组织中的作用机理提供实验依据。
Methods a rat model of cerebral aneurysm was established. The dynamic changes of MMP-2, MMP-9 and TIMP-1 expression were examined in the process of aneurysm formation.
方法制作肾性高血压大鼠脑动脉瘤模型，系统动态观察脑动脉瘤形成过程中MMP - 2、MMP - 9及其特异性抑制物(TIMP - 1)表达的变化。
Objective To investigate the relationship between the ratio of MMP-3 to TIMP-1 and articular cartilage injury after ischemia-reperfusion.
目的探讨缺血再灌注后关节软骨中MMP - 3/TIMP - 1比例变化与软骨损伤的关系。
Expression of Matrix Metalloproteinase-2, -9 and Their Inhibitors TIMP-1, -2 on Lens Epithelial Cells of Aged-related Cataract.
基质金属蛋白酶-2,9及其抑制因子- 1,2在老年性白内障晶状体上皮细胞的表达。
Objective: To construct and identify recombinant adeno-associated virus encoding rat tissue inhibitor of metalloproteinase-1(TIMP-1) full length cDNA.
目的：构建及鉴定载入金属蛋白酶组织抑制因子1（TIMP鄄1）的重组腺相关病毒载体。
Conclusions Overexpression of TIMP-1 exacerbates renal tubulointerstitial injury by enhancing inflammation.
结论TIMP - 1过表达可通过增强炎症加重肾小管间质损伤。
Conclusion the serum mediated with TCM liver-protective drugs could inhibit the TIMP-1 expression of hepatic HSC and promote apoptosis of the activated hepatic HSC.
结论保肝中药复方药物血清能抑制肝星形细胞TIMP 1的表达，并促进活化的肝星形细胞凋亡。
Immunohistochemical streptavidin-peroxidase (S-P) method was used to detect the expression of MMP-9, TIMP-1, in 15 cases with partial hydatidiform moles and 55 cases with complete hydatidiform mole.
应用链霉菌抗生物素蛋白—过氧化物酶免疫组织化学方法检测15例部分性葡萄胎、55例完全性葡萄胎滋养细胞中MMP-9、TIMP-1表达。
Objective: To study the expression of matrix metalloproteinases-9(MMP-9) and tissue inhibitor of metalloproteinases-1(TIMP-1) in placenta from patients with severe pregnancy induced hypertension(PIH).
目的：探讨基质金属蛋白酶9（MMP-9）、金属蛋白酶组织抑制因子1（TIMP-1）在正常妊娠和重度妊娠高血压综合征患者胎盘组织中的表达及其意义。
There was significant difference in serum level of MMP-9 and TIMP-1 between ACS, SAP, and control group.
SAP组血清mmp 9水平高于正常对照组，而血清TIMP 1水平低于正常对照组，也具有统计学意义。
ConclusionThe expression of MMP-2, TIMP-1 and TIMP-2 are closely correlated with the development of the invasive activity of human astrocytoma.
结论MMP - 2、TIMP - 1和TIMP - 2在星形细胞肿瘤组织中的表达与星形细胞肿瘤的侵袭性生物学行为的演进密切相关。
Results: Hydrosalpinx fluid significantly decreased the hatching rate of blastocysts and the concentrations of MMP-9 and TIMP-1 both in blastocysts and culture medium, in a dose dependent manner.
结果输卵管积液组的囊胚孵出率低于无积液组，囊胚及培养液中的MMP-9和TIMP-1低于无积液组，并呈剂量依赖性，MMP-9/TIMP-1随积液浓度增加而降低。
Objective To study the significance of expression of Matrix Metalloproteinase-1(MMP-1) , Tissue Inhibitor of Metalloproteinase-1(TIMP-1) and Proliferating cell nuclear antigen (PCNA) in abnormal scar.
目的：研究基质金属蛋白酶-1（MMP-1）、金属蛋白酶组织抑制剂-1（TIMP-1）、增殖细胞核抗原（PCNA）在病理性瘢痕中的表达及意义。
Objective To determine the relationship between the expression of tissue-inhibitors of metalloproteinases-1 (TIMP-1) and the prognosis of laryngeal carcinoma (LG).
目的：研究金属蛋白酶组织抑制因子1（TIMP-1）在喉癌中的表达情况及其与喉癌预后的关系。
TIMP-1 may promote ventricular remodeling and accelerate the process of the myocardial diastolic dysfunction in hypertensive heart disease.
TIMP - 1可能促进了高血压患者心室重构和心肌舒张功能障碍的进程。
PCNA was found to be negatively correlated with TIMP-1 nuclear distribution, suggesting the TIMP-1-Nuclear-Positive cells might not be in the active proliferation state.
结合文献报导的一些细胞中的TIMP-1核内分布现象，提示TIMP-1在细胞核内的分布可能不是特殊的情况。
Conclusion: MMP-2 and MMP-9 be involved in the invasion of the normal human cytotrophoblast cells, while TIMP-1 and TIMP-2 make this invasion controllable.
结论：MMP一2、MMP一9参与了正常早孕滋养细胞的侵袭的过程，而TIMP-1、TIMP一2使滋养层细胞以一种可控制的形式侵袭。
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