The purpose was to provide simple, robust, easy to implement and feasible approaches for drug-protein binding study in new drug design and therapeutic drug monitoring (TDM).
其目的是为新药研究和治疗药物监测中研究药物-蛋白结合作用提供简单、耐用、易操作和可行的方法。
蛋白结合率低。
Plasma protein binding rate of lofexidine was (about) 38%.
洛非西定的血浆蛋白结合率约为38%。
The serum protein binding rate in dogs was determined by dialysis method.
用透析法测定药物的狗血浆蛋白结合率。
OBJECTIVE To study the plasma protein binding rate of harmine hydrochloride.
目的：测定盐酸去氢骆驼蓬碱的血浆蛋白结合率。
Objective To clone and bioinformatically analyze the full-length sequence of F protein binding protein 1 (FBP1).
目的对命名为F蛋白结合蛋白1（FBP1）的未知基因，克隆其全长基因并进行生物信息学分析。
The serum total thyroxine(T_4) contents of 49 Ganzhou White swine were determined by competitive protein binding.
用竞争性蛋白结合法测定了49头赣州白猪的血清甲状腺素（T_4）含量。
According to our results, it was concluded that the PK parameters differences between human and rat were not due to plasma protein binding.
结果表明人与大鼠药代动力学参数的差异不是由蛋白结合率的差异所导致。
Plasma protein binding influences distribution and the apparent relationship between pharmacologic activity and total plasma drug concentration.
血浆蛋白的结合作用会影响药物的分布，并影响药理活性和总血浆药物浓度间的表观关系。
The principle and regulation effect of high performance frontal analysis (HPFA) and its application in the study of drug-protein binding were reviewed.
综述高效前沿分析法(HPFA)的原理、调节作用及其在药物与蛋白结合研究中的应用。
The performance tests indicate that matrices have well macroporous structure, the protein binding capacity of the prepared anion adsorbent could increase 15 %;
研究表明：复合基质具有良好的大孔结构，所制备的阴离子吸附剂的蛋白质吸附性能能提高15%；
The studies revealed that the resistance formation of rice stem borer was closely involved with the increase of detoxifying enzyme activity, target enzyme insensitivity and protein binding.
已有研究表明：解毒酶活性升高、靶标不敏感性以及蛋白质的螯合作用与二化螟抗药性形成的关系密切。
Conclusion: the method was simple and convenient. The protein binding rates and protein binding parameters of atropine sulfate and scopolamine hydrobromide were determined with the method effectively.
结论：该方法简便易行，能够有效测定硫酸阿托品和氢溴酸东莨菪碱蛋白结合率及蛋白结合参数。
The enantiomer-specific structure of local anaesthetics has large impact on the pharmacokinetic process of these drugs, including absorption, protein-binding ratio, metabolism, and so on.
药物对映体结构特异性对局麻药药代动力学的各个过程都有着很大影响，包括药物的吸收、蛋白结合率、代谢等。
Method: Ultrafiltration and HPLC were employed to measure the conc. of free drug. The difference in protein-binding between cefotaxime alone and together with metronidazole was examined.
方法：采用超滤法结合高效液相色谱法测出游离药物浓度，比较未加和加入甲硝唑后头孢噻肟钠的蛋白结合率。
Method: Ultrafiltration and HPLC were employed to measure the conc. of free drug. The difference in protein-binding between cefotaxime alone and together with metronidazole was examined.
方法：采用超滤法结合高效液相色谱法测出游离药物浓度，比较未加和加入甲硝唑后头孢噻肟钠的蛋白结合率。
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