Objective Preparing specific antibody to prion protein.
目的制备针对朊蛋白的特异性抗体。
Prion protein is a normal constituent of brain tissue in all mammals.
朊蛋白是一种脑组织中所有的哺乳动物的正常组成部分。
It suggests that human prion protein might play a role in controlling cell programmed death.
这提示朊蛋白可能参与细胞程序化死亡的调控过程。
However, the prion protein in scrapie-infected brain tissue differs from normal prion protein in some of its properties.
然而，在感染羊瘙痒病的大脑组织的普利昂蛋白在某些性质上不同于一般的普利昂蛋白。
Objective To investigate the effects of prion protein 106-126 peptide on inducing apoptosis in differentiated PC12 cells.
目的：研究朊蛋白106-126肽段在细胞水平上的毒性作用。
Conclusion Prion protein 106-126 peptide can induce apoptosis in differentiated PC12 cells and present cellular toxicity definitely.
结论：朊蛋白106- 126肽段能够诱导分化后的PC 12细胞凋亡，具有明确的毒性作用。
Objective To study the inhibitive effect of prion protein on the formation of microtubules enhanced by microtubule-associated protein tau.
目的研究朊蛋白对微管相关蛋白介导的体外微管形成的影响。
But no variant of prion protein was able to prevent demyelination when introduced specifically into the Schwann cells that surround and support peripheral nerve cells.
但当向神经末梢周围的雪旺细胞注入这种蛋白时，没有变异的蛋白能阻止退化。
Conclusion: Prion protein 106-126 peptide has cellular toxicity effect on differentiated PC12 cells, and the energy metabolize disorder may be one of the reasons for the toxic mechanism.
结论：朊蛋白106- 126肽段对分化PC 12细胞具有毒性作用，能量代谢障碍可能是其毒性作用机制之一。
However, prion diseases are considered to be representative of other protein precipitation-associated diseases.
然而，阮病毒疾病被认为是其他蛋白相关疾病的典型。
The essence of prion (proteinaceous infectious particle) is a protein.
朊粒的本质是蛋白质。
The prion-protein genes are single-copied and high conservative, but there might be related munity gene existing between animals.
朊蛋白基因是单拷贝基因，高度保守，但在物种间可能存在易感性相关基因。
By exhaustive enumeration, we get the prion-like behavior of protein folding.
通过穷举计算，我们观察到了这种折叠行为。
Whereas mice with their prion-protein gene knocked out seem to be healthy, it is thought that the gene might also help to regulate the growth of stem cells in the brain and bone marrow, Pfeifer says.
然而那些被敲除了普粒子蛋白基因的老鼠看起来很健康，Pfeifer认为这个基因可能也有助于调节大脑和骨髓的干细胞的生长。
Whereas mice with their prion-protein gene knocked out seem to be healthy, it is thought that the gene might also help to regulate the growth of stem cells in the brain and bone marrow, Pfeifer says.
然而那些被敲除了普粒子蛋白基因的老鼠看起来很健康，Pfeifer认为这个基因可能也有助于调节大脑和骨髓的干细胞的生长。
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