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这种药物有一个很大的限制因素，其药效只能持续6个小时。
This drug has one important limitation. Its effects only last six hours.
《柯林斯英汉双解大词典》
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然而，仍然有一个很大的障碍。
However, there is still a big stumbling block.
youdao
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这里有一个很大的障碍。
There is one big snag.
youdao
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因为我会说日语，所以我有一个很大的优势。
As I speak Japanese, I had a very big advantage.
youdao
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我发现他有一个很大的可取之处。
I have found in him one great redeeming feature.
youdao
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尤其是测试过程有一个很大的成功。
The testing process in particular had been a big success.
youdao
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这个技巧有一个很大的优点。
This technique has a major advantage.
youdao
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有一个很大的，挡住了视线。
There's a large that's blocking the view.
youdao
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但是有一个很大的问题。
But there was one big problem.
youdao
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他们有一个很大的成功与这一点。
They had a great deal of success with this.
youdao
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我的英语老师有一个很大的房子。
My English teacher has a big house.
youdao
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这所学校有一个很大的生物实验室。
The school has a large biological laboratory.
youdao
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那所大学的校园有一个很大的操场。
The campus of that university has a very big playground.
youdao
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我有一个很大的压力，我这样做呢？
I have a lot of pressure, I do instead?
youdao
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你看，乔治，有一个很大的泥坑。
Peppa: Look, George. There's a really big puddle.
youdao
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但田鼠种类之间有一个很大的区别。
But there was one big difference between the vole species.
youdao
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这个房子里有一个很大的厨房。
There is a big kitchen in this house.
youdao
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实验证明是有一个很大的撞击效应产生。
It turned out to have a huge knock-on effect.
youdao
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我曾经有一个很大的梦想但不能实现了。
I had a big dream and couldn't achieve it.
youdao
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后山有一个很大的狐狸窝。
There is a big fox den on the back hill.
youdao
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但是，有一个很大的警告。
But there's one big caveat.
youdao
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有一个很大的工业区，是核桃碗的遗址。
It has a huge industrial park and is the site of the Pecan Bowl.
youdao
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父母有一个很大的影响-至少在我身上。
Parents have a great deal of influences - at least mine did on me.
youdao
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但是有一个很大的缺点。
However it has ONE major flaw.
youdao
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房间里有一个很大的壁橱，你可以把你的行李放进去。
The room has a big closet. You can put your baggage in it.
youdao
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他承认，内部和外部环境有一个很大的变化。
He confessed, both internal and external environment has been a big change.
youdao
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他承认，内部和外部环境有一个很大的变化。
He confessed, both internal and external environment has been a big change.
youdao