What seems to be the problem with...?

大概是什么问题？

youdao

What seems to be the problem with those two?

他们俩的关系好像出了什么问题？

youdao

What seems to be the problem with you? You look very upset this morning.

怎么了？今天早上你看上去心烦意乱的。

youdao

What seems to be the problem with you? You look very upset this morning.

怎么了？今天早上你看上去心烦意乱的。

youdao