They can cause substantial personal suffering, impaired quality of life and financial cost.
它们可造成大量个人痛苦、生活质量受损以及经济代价。
These conditions cause premature death and substantial disability.
这些病症造成过早死亡和严重残疾。
It is really a retreat and would cause substantial reconsideration of the overall concept.
这绝对是一个倒退并且会导致全盘计划的重新考虑。
Such a rise, they argue, would 'cause a substantial loss of net employment.
他们说，这样的一个升值幅度会使净就业率受到相当大的打击。
Other features will not cause enough of a performance hit to make a substantial difference.
其他功能不足以造成性能的急剧变化。
Other features will not cause enough of a performance hit to make a substantial difference.
其他功能不足以造成性能的急剧变化。
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