You have made a major mistake.
你犯了一个很大的错误。
In really difficult circumstances, he didn't make a major mistake.
在真正困难的情况下，他没有犯重大的错误。
Top and bottom-pickers usually are trading against the trend, which is a major mistake.
摸顶抄底者通常是逆势交易，这是一个严重的错误。
Top and bottom-pickers usually are trading against the trend, which is a major mistake.
摸顶抄底者通常是逆势交易，这是一个严重的错误。
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