This is the one major drawback of the new system.
这是新系统的一大弊端。
The high cost is a major drawback.
高成本是主要的障碍。
Unfortunately, it has one major drawback.
不幸的是，它也有一个主要缺点。
But it has a major drawback: it's usually impaired by hair.
但是，它有一个很主要的缺点：那就是我们的头发常常会破坏它应有的的效果。
The major drawback with the iPhone is the phone service.
iPhone最大的缺点就是它的通话服务。
The major drawback is in assigning responsibility for quality control.
其主要缺点是无法在质量上确定各自的责任。
As our project evolved, I found that this approach had a major drawback.
随着我们项目的进展，我发现这种方法有一个重要缺陷。
A major drawback of sales promotion is that it is easily copied by competition.
销售促销的一个大缺点是很容易被竞争对手模仿。
However, a major drawback for now is the lack of a national antibodydatabase.
然而，目前一个主要的不利点是缺乏全国性抗体数据库。
However, a major drawback for now is the lack of a national antibodydatabase.
然而，目前一个主要的不利点是缺乏全国性抗体数据库。
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