这时研究可能是有帮助的，但它能导致你的生产计划遭到毁灭性打击。
While that research may be helpful, it can wreak havoc on your production plans.
如果这家工厂倒闭，将给当地居民以毁灭性的打击。
It will be a devastating blow to the local community if the factory closes.
家人在事故中的不幸死亡，对他来说是个毁灭性的打击。
The decease of his family members in the accident was crushing blow to him.
他说，这是一个毁灭性的打击的中央谷的已经十分脆弱的经济。
He says it's a crushing blow for the Central Valley's already fragile economy.
这对我是个毁灭性的打击。
在450年前，伦敦的一场巨大的火灾给这座城市曾带来过毁灭性的打击。
More than 450 years ago there was a great fire which devastated London.
在450年前，伦敦的一场巨大的火灾给这座城市曾带来过毁灭性的打击。
More than 450 years ago there was a great fire which devastated London.
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