A change, or mutation, happens when the order of the letters changes.
当这些字母的排列顺序有所变化时，就会发生基因突变。
By detecting its structure in the tumour tissue, we find that the sum of its deletion or mutation rate reaches 35%.
通过检测肿瘤组织中该基因的结构，发现该基因在肿瘤组织中的缺失或突变率的总和达到35%。
Examples of so-called SNP diseases are sickle-cell anemia and Huntington's disease, where a single variant or mutation has a dramatic effect.
镰状细胞性贫血和亨庭顿综合症就是这样的疾病，单个变异起了很大的作用。
"We already know that the over-expression or mutation of molecules known as NIK and TRAF3 in B cells is associated with human multiple myeloma," said Professor Mackay.
“我们已经知道，在B细胞过度表达或突变的NIK和TRAF3分子是与人类多发性骨髓瘤相关，”麦凯教授说。
Because it has been realized that cancer is not only a disease of defects in gene expression or mutation but also a metabolic disease in that cells need nutrients to grow.
因为人们已经认识到，癌症不仅仅是因一种基因表达或变异缺陷而导致的疾病，同时也似一种代谢性疾病，因为肿瘤细胞的生长需要营养物质。
Because it has been realized that cancer is not only a disease of defects in gene expression or mutation but also a metabolic disease in that cells need nutrients to grow.
因为人们已经认识到，癌症不仅仅是因一种基因表达或变异缺陷而导致的疾病，同时也似一种代谢性疾病，因为肿瘤细胞的生长需要营养物质。
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