PCR-capillary electrophoresis is convenient to screen NPM1 mutations of AML in clinical practice.
AML的NPM1基因突变临床检测采用PCR-毛细管电泳法更方便。
Mutations in exon 12 cause cytoplasmic NPM1 localization, and consequently contribute to tumour development.
第12外显子突变导致NPM 1胞浆异位从而发生肿瘤转化。
Conclusions Genotypes defined by the mutational status of NPM1, FLT3, CEBPA, and MLL are associated with the outcome of treatment for patients with cytogenetically normal AML.
结论：由npm 1,FLT3,CEBPA，和MLL基因的突变状态所界定的基因型与细胞遗传学正常的急性髓细胞白血病患者的临床治疗结局之间存在相关性。
Conclusions Genotypes defined by the mutational status of NPM1, FLT3, CEBPA, and MLL are associated with the outcome of treatment for patients with cytogenetically normal AML.
结论：由npm 1,FLT3,CEBPA，和MLL基因的突变状态所界定的基因型与细胞遗传学正常的急性髓细胞白血病患者的临床治疗结局之间存在相关性。
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