• Nanopore sequencing can cope with much longer strands, which should help speed things up.

    纳米孔测序还可以应付更长的链,这也将帮助加速这项工作。

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  • They also need to determine exactly how the DNA will be decoded when it passes through the nanopore.

    研究人员还需要精确的确定DNA通过纳米孔时将如何被破译。

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  • Since the molecule is easily ionized, voltage drops across the nanopore help "pull" the DNA through.

    由于分子很容易被电离,通过纳米孔的电压落差有助于牵引dna穿过微孔。

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  • This also involves a nanopore in an AHL protein, but the DNA strand does not pass through the nanopore intact.

    这也需要在AHL蛋白质上有个孔道,但是DNA链不再原原本本地穿过纳米孔。

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  • The most promising way to make such cheap, rapid sequencing a reality is an approach called “nanopore sequencing”.

    让这种既便宜、又快速的测序工作成为可能最有希望的途径,是一种称作“纳米孔测序”的办法。

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  • A detector operably coupled to a nanopore may detect labeled amino acid residues as they pass through the nanopore.

    当被标记的氨基酸通过纳米孔时,与纳米孔可操作地相连的检测器可以检测它们。

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  • Researchers took a 200-millimeter silicon-wafer chip and drilled a 3-nanometer-wide hole (known as a nanopore) through it.

    研究人员那一片200毫米的硅片芯片并在上面打上直径3纳米的孔(称为纳米孔)穿过它。

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  • Currently, the most commonly studied nanochannel is a silicon nanopore, made by drilling a hole through a silicon membrane.

    目前,最常见纳米通道的研究是通过在硅表面钻了一个洞的硅纳米孔。

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  • Scientists have shown that an applied electric field can drive the DNA molecules through a nanopore, a tiny hole in a membrane.

    科学家们过去已经展示过,外加电场可以用来推动DNA分子通过纳米孔,即细胞膜上的微孔。

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  • In the journal Nanotechnology, the physicists report the first experiment to move DNA through a solid-state nanopore using magnets.

    在纳米技术杂志里,物理学家们报告了首次使用磁铁移动DNA通过固态纳米孔的试验。

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  • There is a clear sense that the field of nanopore sequencing is gaining momentum, with new developments occurring almost every month.

    毋庸置疑的是,纳米孔测序领域正在一天天地发展壮大,几乎每个月都有新的改进诞生。

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  • Yet even a nanopore reading 50 bases per second would take about two years to sequence a whole genome, which contains around 3 billion genetic letters.

    然而即使一个纳米孔每秒读取50个碱基,这仍要花费约两年时间来测序整个基因组——大约30亿个碱基。

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  • Nanopore sequencing is expected to be much cheaper because it gets around the main problem that has kept the cost of conventional methods so high.

    由于纳米孔测序客服了传统方法中最耗费开支的技术问题,所以会廉价很多。

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  • The idea is that individual base pairs (the four chemical "letters" of the DNA alphabet) can then be read off one at a time as they pass through the nanopore.

    这个想法是单个的碱基对(DNA密码的四个化学字母)在他们通过纳米孔的时候,能流利地被一个一个读出(那四个字母是指a、T、C、G,译者注)。

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  • Dr Sanghera says Oxford Nanopore has developed an electronic cartridge system called GridION, based on "lab on a chip" technology, for exonuclease sequencing.

    桑赫拉博士说“牛津纳米孔公司”已经发明出了一个基于“片上实验室”技术,叫做“网离子”的电子模块系统,用来核酸外切酶的测序。

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  • Using self-consistent field calculation, the new equilibrium morphology of a diblock copolymer melt confined in a brush-covered cylindrical nanopore can be found.

    利用自洽场方法研究两嵌段共聚物受限于接枝均聚物链(聚合物刷)圆孔中的自组装相形貌。

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  • It would also be more accurate: because the bases are still attached to one another, there is no chance that they will pass through the nanopore in the wrong order.

    这会比核酸外切酶测序更快,也会更加精确:因为碱基彼此间仍然相连,不会以错误的顺序通过纳米孔。

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  • Other labs have experimented with similar nanopore-based approaches to sequencing but have found it difficult to control how quickly the DNA strand feeds through the nanoscale hole.

    其他实验室已经试验过类似的纳米孔测序方法,但研究人员发现,很难控制DNA链穿过纳米孔的速度。

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  • Objective To observe the growing shape and function of Madin-Darby canine kidney (MDCK) cells implanted on the polysilicon nanopore membrane by micro-electro-mechanical system (MEMS).

    目的 利用多晶硅纳米孔技术人工合成一种多孔隙薄膜,并在薄膜上培养狗肾脏细胞(MDCK),观察细胞生长情况及膜的生物相容性。

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  • It is a time-consuming process and a significant bottleneck, says Gordon Sanghera, the chief executive of Oxford nanopore, a firm set up in 2005 to commercialise Dr Bayley's work on nanopores.

    这是一个很耗时的过程并且是一个重要控制步骤,戈登•桑赫拉说道。他是牛津纳米孔公司的行政长官。这家公司创立于2005年,以使贝利博士在纳米孔上的工作商业化。

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  • So Oxford Nanopore has also been looking at an alternative approach, called exonuclease sequencing, in conjunction with Illumina, an American firm that is the market leader in rapid sequencing.

    所以“牛津纳米孔公司”,和快速测序领域的领头羊,“Illumina公司”也在一同研究一种叫做“核酸外切酶测序”的办法。

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  • The specimen for plane-view observation was prepared by peeling nanopore template film off the AAO template, widening and broking, and the broken film was put on the copper grid for observation.

    纳米孔薄膜的正面观察是把纳米孔膜从模板上取下后通孔并碎化,把微小碎片放在铜网上观察;

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  • The specimen for plane-view observation was prepared by peeling nanopore template film off the AAO template, widening and broking, and the broken film was put on the copper grid for observation.

    纳米孔薄膜的正面观察是把纳米孔膜从模板上取下后通孔并碎化,把微小碎片放在铜网上观察;

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