• This methylation of GR appears to make the individual more tuned in or sensitized to stress, so they will react to it quicker mentally and hormonally.

    这种GR的甲基化似乎使个体对压力更加了解或敏感,他们会在心理上和荷尔蒙分泌上反应更快。

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  • Oxidative methylation of toluol to styrene is a new process.

    甲苯氧化甲基化合成苯乙烯是一种新工艺。

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  • The ability to track methylation is thus scientifically important.

    追踪甲基化的能力因而在科学上有其重要性。

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  • Various factors can influence methylation, including environmental conditions.

    很多因素都可以影响甲基化,包括环境条件。

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  • "DNA methylation in the kidney is different from DNA methylation in the liver," he says.

    “肾脏内的DNA甲基化不同于肝脏内的,”他说。

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  • DNA methylation plays an important role in gene regulation and animal development.

    DNA甲基化在基因调节和动物发育中起着重要作用。

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  • DNA methylation is the unique natural covalent modification of vertebrate animals.

    DNA甲基化是脊椎动物DNA唯一的自然共价修饰方式。

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  • DNA methylation is a prominent epigenetic mark and extensively found within plant genomes.

    DNA甲基化是显著的表观遗传标记,并且大量发现于植物基因组中。

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  • Here, we review the role of epigenetics in aging and longevity with a focus on DNA methylation.

    这里,我们回顾了表观遗传学在衰老和长寿中的作用,集中在DNA甲基化。

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  • DNA methylation and its aberrance play an important role in the human development and tumorigenesis.

    DNA的甲基化及甲基化异常在人体发育和肿瘤的发生中起着至关重要的作用。

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  • DNA methylation in the promoter regions is a powerful mechanism for the suppression of gene activity.

    在启动子区域的DNA甲基化是抑制基因活性的一种重要机制。

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  • And in rats, such methylation makes young animals especially sensitive to stress, and also fearful of novelty.

    而老鼠试验表明,这样的甲基化过程让幼小动物对压力尤其敏感,对新鲜事物也感到恐惧。

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  • But the patterns of methylation change as we grow older. Which was a clue that measuring methylation might give away age.

    但是甲基化的发生模式会随着我们年龄的增加发生变化,这也就为通过测定甲基化确定人体年龄提供了可能。

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  • Whether cytosine methylation is the explanation for this difference has yet to be tested, but something is clearly happening.

    胞嘧啶甲基化是否能够解释这种差异还有待考察,但是的确是有些什么东西存在着。

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  • One of the best known epigenetic factors is DNA methylation, which is a major mechanism for regulation of gene expression.

    表观因子中最著名的一个是DNA甲基化,它是基因表达调控的一个主要机制。

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  • But in the daughters of obese fathers, the level of methylation of this gene was around 25% of the level seen in the control daughters.

    但在父亲肥胖的雌鼠身上,该基因的甲基化水平仅占对照组雌鼠的25%左右。

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  • The methylation of histone lysine is an important covalent modification at its tails and plays a key role in epigenetic regulation.

    组蛋白赖氨酸甲基化是组蛋白尾段发生的一种重要共价修饰,在基因的表观遗传转录调控中起着关键的作用。

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  • When you use animal models and do the things that are commonly done in assisted reproduction, the answer is yes—it affects DNA methylation.

    “如果你在动物模型上模拟辅助生殖你会发现答案是肯定--它能影响DNA的甲基化”。

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  • The process, known as DNA methylation, is one mechanism of epigenetic change, heritable change that does not alter the sequence of DNA itself.

    该过程被成为DNA甲基化,是表观遗传变化的一种,属于不会改变DNA序列的可遗传变化。

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  • The presumption is that the pattern of methylation, by controlling which proteins are manufactured, helps determine what type of cell is produced.

    推论是甲基化模式通过控制蛋白质的合成从而决定形成什么样的细胞.

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  • Andrew Hudson at the University of Edinburgh says there is a clear implication that "DNA methylation and epigenetic changes are important in evolution."

    爱丁堡大学的AndrewHudson表示,这明显意味着“DNA甲基化和表观基因变异在进化中是非常重要的”。

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  • Cancer cells exploit this process, putting some genes in "cold storage" or "turned off" by modifying the cell DNA in a process known as methylation.

    癌细胞正是利用这一过程来发挥作用,即通过甲基化作用修饰细胞DNA,从而将一些基因打入“冷宫”或关闭基因的表达。

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  • Moreover, the methylation patterns were clustered together in large swaths of DNA, suggesting an epigenetic pattern linked to humans’ early environments.

    而且,甲基化的模式在DNA长链中被聚集到一起,显示了与早期环境相关的后天模式。

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  • DNA methylation might play a role in the early diagnosis, prognosis judgement and reverse of precancerous lesions of malignant tumors in the future.

    DNA甲基化可能在肿瘤的早期诊断、预后判断及癌前病变的逆转方面发挥一定作用。

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  • Future research could peg where certain methylation differences are associated with specific diseases, then target those areas with drugs or other treatments.

    未来可以深入研究某种甲基化差异和具体疾病的关系,然后针对那些区域用药治疗。

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  • The aberrant methylation in some genes is strongly associated with colorectal cancer, and this methylation occurs during the early stage of colorectal cancer.

    某些基因异常甲基化与结肠癌发生密切相关,且常见于结肠癌发病早期。

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  • In another part of the brain, the cerebellum, however, which is not involved in mood, there were no differences in the levels of methylation between the two groups.

    作为对比,大脑的另一部分、与情绪无关的小脑,它里面基因的甲基化水平在两组中并无差异。

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  • Their team examined the methylation of the glucocorticoid-receptor gene in a group of children ranging in age from ten to 19 years, and in those children's mothers.

    他们的团队对一组10到19岁的儿童进行了糖皮质激素受体基因甲基化的检测,并对他们的妈妈做了同样的检测。

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  • Taken together, these results suggest that glucocorticoid-receptor-gene methylation happens in the fetus in response to a mother's stress, and persists into adolescence.

    总体看来,这些结论表明胎儿糖皮质激素受体基因的甲基化是由于母亲压力过大引起的,并且其影响将会持续到青春期。

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  • He didn't speculate as to which is the more likely culprit, but said that many things, such as gene mutations, could cause defects in methylation that might result in infertility.

    至于哪个更可能是原因他并没能做出预测,但是他说许多东西如基因突变也能导致甲基化的缺陷,这也可能导致不育。

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