What extracellular matrix you have in any particular tissue is there because there's a balance between it being produced by one kind of cell and digested by another, and you're in this sort of state of dynamic equilibrium.

特定组织中,细胞外基质的多少,取决于一个,分泌与降解的平衡,这是一种动态的平衡关系

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You have mechanisms inside your natural mechanisms inside your cell that allow the cells to degrade unwanted RNA sequences.

人体内细胞的这种自然机制,有助于细胞降解不需要的RNA序列

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Certain double stranded RNA sequences will cause in the cell a process of degradation of very specific RNA sequence.

一些双链RNA序列能够在细胞中开启,特定RNA序列的降解程序

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Of course, if you degrade the messenger RNA at a rapid rate then you'll stop expression of the cells.

如果降解信使RNA的速度很快的话,就会停止细胞的表达

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You could interfere at these later levels as well, for example, by augmenting RNA degradation.

你也能干扰一些下游的调控水平,例如,通过增强RNA的降解

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Dicer is an internal cellular mechanism for degrading RNA's.

icer是细胞降解RNA的内在机制

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The end result is you can design now very specific double stranded RNA sequences, that when delivered into cells again will activate this process of natural degradation of an existing messenger RNA.

最终的结果是,你现在能够设计针对性很强的,双链RNA序列,当这段序列被转入细胞后会激活,对已有信使RNA进行降解的过程

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Now the nice thing about this is that the degradation mechanisms seem to persist for some period of time, beyond the time at which you deliver the double stranded RNA; whereas, obviously, this mechanism here is only going to exist for as long as the anti-sense sequence is present.

而好消息是降解过程会持续一段时间,比你转入双链RNA的时间要长,但是,这种机制只会在,有反义链的时候发挥作用

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