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That can happen but that's abnormal, but changes in maybe the chemistry of the backbone that holds the nucleotides together.
这可能发生的,但属于非正常的变化,而是改变诸如维持核苷酸序列的,主链的化学结构
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It's phosphate, carbon, carbon, carbon, phosphate, carbon, carbon, carbon, phosphate and it has this structure hanging off the side.
就是磷酸基与戊糖的碳反复连接,如此循环往复,这种结构构成了主链的一边
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The backbone's on the outside of the molecule like the upright struts of a ladder on the outside of a ladder.
主链位于DNA分子结构外侧,像梯子两侧上下的支柱,记住是梯子外侧
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This is - what this diagram shows you is-- the forces that hold these individual strands of DNA into a double stranded form.
你们可以看看这个图表,演示了连接两条DNA长链为双螺旋,结构的化学力
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When these nucleotides get polymerized to form a long DNA molecule they all get polymerized in exactly the same way, the chemistry is the same.
当这些核苷酸多聚化,形成一条长链DNA分子时,它们的聚合方式和,化学结构都完全相同
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It has to do with the nature of this complementary binding between double stranded DNA and the fidelity of this base pair matching in forming stable DNA molecules.
这些特性能从根本上解释,为何DNA双链的碱基能互补配对,以及在形成稳定的DNA分子结构时,碱基互补配对为何具有一致性
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That's because you have to satisfy this base pair matching in order to have hydrogen bonding in each of the struts of the ladder in order to form a stable structure.
NA双链要满足互补配对原则,以使碱基对之间,形成氢键,从而形成稳定的双链结构
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When it's double stranded this gene can't be translated, because you have to have the single strand in order for the transfer RNA to bind and for this process of translation to take place.
当基因处于双链结构状态时,是不能进行翻译的,因为必须把双链拆开得到单链,才能结合转运RNA并开始翻译过程
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The native structure is this double stranded structure here and if I heat it up slightly and I add some base, so under slightly basic conditions, these molecules will fall apart because you've created conditions where the hydrogen bonding is no longer favorable so they peel apart.
原始结构,在这里就是指DNA双链,如果我稍微加热,并且加入一些碱,在弱碱性的条件下,这些配对碱基会分开,这是因为在一定条件下,碱基对之间的氢键,不再稳定并且会断裂分开
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Now DNA is a double helix and I've only shown you one part of the helix, right? I've shown you one upright strut and a base hanging off of it, but it forms a double helix because complementary strands of DNA strongly associate with one another and that's a very stable structure.
NA是双螺旋,我只是给你们讲了螺旋的一边,我给你们演示,一条链的支柱及碱基团,但其能构成双螺旋,是因为DNA是完全互补的两条链,彼此之间结合紧密,结构异常稳定
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