• Enzymes work best, enzymes are proteins that catalyze chemical reactions and our bodies operate by elaborate networks of chemical reactions, When we're off from that temperature then they don't work properly.

    这个例子再好不过,是一种具有催化作用的蛋白质,人体依靠精密复杂的化学反应网络来运转,如果我们体温与之相差较大,这些就不能正常工作

    耶鲁公开课 - 生物医学工程探索课程节选

  • If that protein is an enzyme then you've and you've switched it from an 'off' position where it's not catalyzing a reaction to an 'on' position where it is, you've changed the biochemical state of the cell, you've changed the chemical reactions that can occur within the cell, and you've changed its behavior.

    如果这种蛋白是一种的话,你就能够将从无催化作用的静息态,激活至能催化反应的激活态,你改变了细胞的生化状态,也改变了细胞内发生的化学反应,改变了细胞的行为

    耶鲁公开课 - 生物医学工程探索课程节选

  • It's not as simple as DNA going to RNA going to protein, because proteins need to be present in order to make these things happen as well.

    基因表达不是简单的从DNA到RNA,再到蛋白质,因为整个过程需要,不同的催化作用

    耶鲁公开课 - 生物医学工程探索课程节选

  • If I took this same restriction enzyme and tried to cut the chromosomal DNA of a sickle patient, it wouldn't cut at that point because the wrong sequence is there.

    而如果我用同样的限制,去切割病人的染色体DNA,那该是不会起作用的,因为基因序列不对

    耶鲁公开课 - 生物医学工程探索课程节选

  • It operates in a similar fashion to DNA polymerase in that it denatures locally or opens up the double stranded DNA, but it's different in that it creates a new polymer from the DNA template in the language of RNA, using RNA nucleotides and not DNA nucleotides.

    它的作用机制类似于DNA聚合,在局部使DNA双链变性,解旋,但不同的是,它合成了一个基于DNA模板的,使用RNA编码语言的新聚合物,即使用核糖核苷而非脱氧核糖核苷

    耶鲁公开课 - 生物医学工程探索课程节选

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