It's a single gene defect and we know exactly where the genetic defect is in sickle cell.

是一种单基因缺陷,而且我们准确地知道,镰状红细胞贫血的基因缺陷在哪里

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Usually this is a disease that's caused by a defect in a single gene.

通常在疾病是由,单基因缺陷引起时才可行

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It's on the gene for hemoglobin and the hemoglobin that you produce if you have sickle cell anemia is not quite right because there's one base difference.

这个缺陷基因和血红蛋白有关,如果你有镰状红细胞贫血症,那你所产生的血红蛋白就不太正常,因为这里有一个碱基不同

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One way is to replace a gene that's defective in a disease.

其中之一是置换,导致某种疾病的缺陷基因

耶鲁公开课 - 生物医学工程探索课程节选