The Protestant Reformation, and especially the rising energies of Puritanism in the early seventeenth century, are beginning to do a lot to change this state of affairs.

新教宗教改革，尤其是活力不断上升的清教主义,在17世纪早期，为了改变这种状态开始做出许多努力。

耶鲁公开课 - 弥尔顿课程节选

It's a switch that from outside can be used to change the life of a cell.

这种来自外源的变化能够改变细胞的状态

耶鲁公开课 - 生物医学工程探索课程节选