-
We're going to talk about how they're prepared, but it's a preparation that is intended to stimulate your immune system.
我们会讲它们是如何做准备的,它通过刺激你的免疫系统来进行准备
-
People have tried to produce viruses that are different, adenoviruses for example, that your immune system can't recognize.
人们尝试制造一些不同的病毒,就拿腺病毒来说,让免疫系统无法识别
-
It's simply your psychological immune system will become stronger, hopefully already by the end of this semester.
只是你的心理免疫系统会变得更强，希望在本学期未就见成效。
-
Usually it's done by taking all or part of the infectious agent, and showing them to your immune system in some way.
通常它会带着全部或部分抗原介质,并以某种方式呈递给你的免疫系统
-
What happens when that recognition takes place is that your immune system gets activated, and the activation that happens usually involves two things.
当识别进行时会发生什么呢,那时免疫系统会激活,免疫系统的激活通常包含两个过程
-
So a vaccine is designed in order to engage that biology, in order to provide antigens that will stimulate specifically your immune system.
所以疫苗的作用就是参与这个生理活动,提供抗原 来刺激你的免疫系统
-
That is, mix it with things which make it more make your immune system respond more strongly.
也就是说,增大剂量以使,你的免疫系统产生强烈的反应
-
And those words mean different things: immunogenic means that it stimulates your immune system for a response; pathogenic means that it causes a disease.
这两个词有不同的意义,免疫效应是指,刺激免疫系统产生免疫应答,致病性意指它能使你患病
-
Learning how to turn on your immune system to protect you from a specific pathogen turns out to be very particular to that pathogen.
它发动你的免疫系统来保护你,免受某种病原体的侵袭,只是针对这种特定病原体
-
You could imagine that you've got virus that's propagating inside your cells, making more and more virus, your immune system really responds well to that.
你可以想象,病毒在你的体细胞内繁殖,数量越来越多,你的免疫系统对此反应非常之强烈
-
And so this slide just illustrates that in a simple way, the range of different kinds of organisms that your immune system is trying to--whoops!
这个幻灯片只是简要概括了,各种不同微生物的范围,你的免疫系统正在尝试,噢
-
The reason for that complexity is because your immune system needs to be able to respond to all the potential foreign invaders that we could encounter.
整个系统之所以如此复杂是因为,免疫系统需要应对所有,我们要面对的来犯之敌
-
Because it infects your cells and reproduces, your immune system responds much more vigorously.
由于它会感染你的细胞并且繁殖,所以你的免疫系统会有很强烈的反应
-
That shouldn't be too surprising given what we talked about last week, that your immune system, the adaptive immune system in particular, responds to individual antigens differently.
你们不必惊讶,上周我们讲过免疫系统,特别是适应性免疫系统,对不同抗原的应答是具有特异性的
-
So, what that really means, you know, from last week's lecture, is that the vaccine stimulates these particular cells in your immune system to give you immunity.
所以,这就意味着,通过上周的课程,你们知道,疫苗通过刺激免疫系统中的,特定细胞来使人获得免疫力
-
Now, normally that's a good thing because if you're out in the world and you get infected with adenoviruses you recover from it, your immune system can get rid of it.
通常情况下这是好事,这可以让暴露在户外的你,免于腺病毒的侵害,你的免疫系统可以清除病毒
-
It's the way, for example, that foreign molecules or antigens get presented to cells of your immune system in order to start the process of making an immune response, so sometimes a cell/cell interaction.
通过这种方式,外源分子,或者说抗原,进入到免疫系统的细胞中后,就会开启免疫反应过程,有时候就是细胞之间的相互作用
-
But this antigen presenting cell is more likely a professional antigen presenting cell, or a subset of cells of your immune system that are specialized in ingesting foreign particles and displaying their contents to the rest of the immune system.
但这种抗原呈递细胞更加类似于,专职抗原呈递细胞,或者是体内免疫细胞中的一个亚群,专门从事吞噬异己物质,并告知免疫系统的其他细胞的工作
-
And so we talked very briefly last time about this business of antigen presentation, how your immune system-- one of the things that it does especially well, is recognize what's part of you and what's not part of you.
上次我们简单的提到过,有关抗原呈递的一些知识,你的免疫系统如何,这也是免疫系统尤其擅长的一点,就是识别哪些部分属于你,哪些不属于
-
How is your immune system going to recognize that this virus is there causing bad results if it's living inside of a cell and doing all its business inside a cell where antibodies can't get to it?
你的免疫系统怎样才能识别,作恶多端的病毒呢,如果它隐藏在细胞中进行繁殖,而抗体又无法进入细胞,那该怎么办
-
So, these memory cells are a way that your immune system keeps track of antigens that it's been exposed to for even if maybe the plasma cells that were producing antibody in response to the initial exposure have died and disappeared.
所以,这些记忆细胞,是人体免疫系统记忆抗原的一种方法,即使由浆细胞产生的抗体,在初次免疫应答中全部被消灭,记忆细胞仍然能迅速分化为抗体分泌细胞
-
So, those wrong proteins get presented on MHC1 and your immune system can kill the cell because it's a tumor cell.
所以 当这些错误的蛋白,同MHC1一起被呈递,你的免疫系统就可以消灭这些肿瘤细胞
-
Because this antigen gets expressed in the context of MHC2, your immune system responds differently.
因为这些抗原同MHC2共同表达,所以你的免疫反应就会不同
-
An antigen expressed in the context of MHC stimulates your immune system.
同MHC共同表达的抗原,激活了免疫系统
-
Well, the way that your immune system recognizes it is that all the cells of our body express a molecule on their surface, a membrane protein called the MHC1 complex.
而免疫系统识别的方法是,身体内所有细胞在其表面表达一种分子,一种叫做MHC1复合体的膜蛋白
-
The way that they appear in your body tells the immune system something about where they came from.
抗原在体内出现的方式,向免疫系统表明了抗原的来源
-
Then, your muscle cells would start producing Hepatitis B surface antigen and your immune system recognizing that's a foreign protein would start responding to it.
于是,肌肉细胞将会,开始制造乙肝表面抗原,然后免疫系统就会识别出,那是外来蛋白质并且产生免疫应答
-
A problem with adenoviruses is that your immune system recognizes them, and if your immune system recognizes the virus then it can attack the virus and eliminate it from the body.
关于腺病毒有个问题,免疫系统会识别腺病毒,如果免疫系统识别了这些病毒,就会进而攻击并从体内清除病毒
-
Because this is not a virus at all, but it's a virus subunit, your body doesn't respond to it as strongly, your immune system doesn't respond to it as strongly.
因为这根本不是病毒,而是一个病毒亚基,机体对其反应不是那么强烈,免疫系统不会产生强烈的应答
-
One of the beautiful things about antibodies is that one your immune system is able to make antibodies against all the thousands, ten thousand, hundred thousand different pathogens that you'll come into contact with in your lifetime.
抗体的一个绝妙之处就在于,你的免疫系统可以分泌抗体来对抗,成千上万的 甚至数以十万计不同病原体,这些病原体都是你一生中可能会遇到的
应用推荐