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We know now that it's caused by a related virus, called vaccinia, remember the virus that causes smallpox is called variola.
我们现在知道这病由一种相关的病毒引起,这种病毒叫牛痘病毒,想想天花病毒也被叫做牛痘病毒
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The virus is not killed so It's a live virus, which is actually going to infect your intestinal system and reproduce.
病毒没有被杀死,那么它就是活性病毒,也就意味着它将会,侵入你的肠道系统并且会繁殖
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In fact, a real powerful virus would skip the respiratory system altogether, even better than a cold virus.
事实上，真正强有力的病毒,会跳过呼吸系统，比感冒病毒好的多。
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The idea being if I find a pattern across multiple people's computers maybe all of those people are infected with the same kind of malware or virus or worm.
如果我从不同人的计算机中发现了一个模型,这就说明,所有那些人的计算机都感染了相同的,恶意软件，病毒或蠕虫。
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So, that was a naturally occurring attenuated virus that could be produced into a vaccine that didn't cause the disease.
因为天花病毒存在天然的衰减病毒,这种衰减病毒可以用来,直接生产不致病的疫苗
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The cells would be basically little reactors for generating lots of virus so you could make lots of virus to study.
这些细胞会变成增殖反应堆,从而产生大量病毒,由此可以得到大量供研究的病毒
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It's really just the result of the virus dividing within cells of your skin, and producing a lot of dead cells.
这便是病毒在皮肤细胞内部,分裂的结果,这个过程会产生大量的死亡细胞
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In other cases, the virus propagates in such high numbers that release is literally an explosion of the cell.
在另一些时候,病毒的数量相当大,那么释放病毒就会使细胞的爆裂
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So, this is a cell that's infected with a microorganism, it's infected with a virus, let's say it's infected with influenza virus.
这是一个感染了微生物的细胞,它感染了一种病毒,就说是感染了流感病毒吧
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But unlike the Cowpox virus, vaccinea, that we talked about before, this is the real disease causing agent.
但是同我们之前曾讨论过的,牛痘病毒疫苗的不同之处在于,这是可以直接致病的病毒
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They also found some stockpiles of the virus from the 1950s that they still had on an Army base in Maryland,I think.
政府也在马里兰军队驻地发现了,从十九世纪五十年代储存到现在的病毒
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So, some of these cases were probably due to polio that was transmitted by incompletely killed virus that was present in the vaccine.
因此,那些病例的发病的原因,是被那些疫苗中携带的,没有被完全杀死的病毒感染
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So, you couldn't introduce the live virus in because that would cause the disease not just immunity.
所以 不可以直接接种活体病毒,因为这会使人致病而不仅是引起免疫应答
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One can also purify parts of the protein, that is, parts of the virus, that is, "Do I really need to deliver the whole virus?"
人们还可以纯化部分蛋白质,也就是病毒的某些部分来制造疫苗,那么还需要接种完整的病毒吗
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And this is what's characteristic of smallpox, is that as the virus spreads through your body, it particularly, it particularly affects cells of your skin.
这是天花的特征,当病毒传遍全身时,它特别的,特别地作用于皮肤细胞
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In the Sabin vaccine, or the oral polio vaccine, now you have a non-virulent virus.
在沙宾疫苗,即口服小儿麻痹症疫苗中,存在非致病性病毒
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What the cold virus does is evolve different strategies to cause it to reproduce.
感冒病毒进化成不同物种,使之得以繁衍。
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Hepatitis is a virus that specifically affects the liver, so viruses are often specific to certain kinds of cells.
肝炎病毒就可以特异性的感染肝细胞,因病毒通常都有细胞特异性
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They found that certain cells, in particular, epithelial cells from monkey kidneys, were very effective at propagating the virus.
他们发现有些细胞,尤其是在猴肾脏的上皮细胞中,这种病毒能够有效地增殖
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That's important, too, because you need to be able to tell if the virus is present in the human population.
这一点也非常重要,因为你要能够分辨出,人群中是否有人感染了天花病毒
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If you just introduced this polio virus, which you could make in large quantities into people now, you would be causing polio.
如果你直接接种脊髓灰质炎病毒,将大量的病毒直接接种到人体,就会引起小儿麻痹症
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The government, after this time, did issue contracts to manufacturing companies to produce new quantities of the virus.
在此事件之后,美国政府,和病毒生产企业签了,生产一些病毒的合同
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And so even people that got vaccinated, most of us either have questionable or no protection against the virus at this point.
所以就算那些接种过天花疫苗的人,到那时候也不一定,或者压根无法抵御病毒
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So, they don't start killing all the cells in your respiratory system; they only kill the cells that are harboring the virus.
所以它们不会杀死所有呼吸系统内的细胞,只杀死那些被病毒感染的细胞
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It could have been corrupted because a virus was inside of it so it was making foreign proteins.
细胞被损害的原因是,病毒在其中生产了外源蛋白
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Maybe you don't need the whole virus, but you could just use a piece of the virus,right?
也许你并不需要完整的病毒,你只需使用病毒的一部分
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You infect them with the virus, and you let the cells, in culture, produce the virus.
再用病毒感染它们,使培养基中的细胞产生病毒
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So, Hepatitis is already infecting cells of their liver, their liver is actively making new virus.
乙肝病毒已经感染了他们的肝细胞,他们的肝脏正在迅速地产生新的病毒
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Formaldehyde cross-links proteins, so, if you treated this virus with Formaldehyde, even it was able to enter a cell, it couldn't break down anymore.
甲醛使蛋白质发生交联反应,因此,如果你对病毒使用了甲醛,即使它可以侵入细胞,它也不能够再进行分解
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You could use cell culture, so you don't have to grow the virus naturally in animals.
你可以利用细胞培养技术,那你就不必在动物身上培养病毒
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