If the immune system recognizes only small pieces of the virus and mounts an immune response to that, how about if I just take these pieces of a virus like some structural subunit, some piece of protein and use that as a vaccine?

如果免疫系统识别出病毒的一小段,就可以诱发起免疫应答,那么如果我仅用一小部分病毒,比如一些结构性亚基 一些蛋白质的片段,来作为疫苗的话,会如何呢

耶鲁公开课 - 生物医学工程探索课程节选

We've talked about killing a virus by cross-linking it, for example, to make a substance that looks like a vaccine-- looks like a virus but can't replicate.

例如,我们谈论过,通过蛋白交联来杀死病毒,以便制造出一种类似疫苗,应该是类似病毒但却无法进行复制的物质

耶鲁公开课 - 生物医学工程探索课程节选

So, you cross link all the proteins in the virus, and you make a particle that looks like a virus but it can't act like a virus any longer because it can't replicate.

当病毒中所有的蛋白质交联后,就得到了一种看上去像病毒,却无法致病的病毒,因为这种病毒不能进行复制

耶鲁公开课 - 生物医学工程探索课程节选

Hopefully their immune systems will respond to it like the real virus but it won't be capable of replication because we've chemically cross linked it so it can't go through its life cycle.

人体的免疫系统,就会对该病毒产生免疫应答,但灭活的病毒不能复制,因为我们已经对它做了化学处理,使它无法进入生命周期

耶鲁公开课 - 生物医学工程探索课程节选