In fact, temperature is such a carefully controlled parameter that when it changes just a little bit by a couple of degrees, we know that something's wrong.

事实上,体温被控制得如此精细,哪怕只改变几度,我们就能感觉出来不对劲

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That - irreversible changes happen all the time too but here I'm talking about very subtle small changes where you're changing the structure of the protein but only a little bit such that it can go back.

这种不可逆的改变时时刻刻都在发生,但我在这里想讲的是,对蛋白质结构进行微小的改变,小到这种改变是可逆的

耶鲁公开课 - 生物医学工程探索课程节选