Sometimes subtle changes in the structure of a protein can convert it from an active state into an inactive state.

有时蛋白质结构上一些很小的变化,就能将其由激活态转变为非激活态

耶鲁公开课 - 生物医学工程探索课程节选

That's one of the beauties of proteins as working molecules is that their structure can be changed by subtle means.

蛋白质作为一种生物活性分子,其优势之一是,能够通过精细的方法改变其结构

耶鲁公开课 - 生物医学工程探索课程节选

That - irreversible changes happen all the time too but here I'm talking about very subtle small changes where you're changing the structure of the protein but only a little bit such that it can go back.

这种不可逆的改变时时刻刻都在发生,但我在这里想讲的是,对蛋白质结构进行微小的改变,小到这种改变是可逆的

耶鲁公开课 - 生物医学工程探索课程节选