They have a substantial reality within the fictional context, the mimetic context, of this epic. These are angels.

他们在这篇史诗虚构的模仿得来的，内容中具有极大的现实意义，他们是天使。

耶鲁公开课 - 弥尔顿课程节选

But I think there are substantial proportion of faculty who really do have a commitment defined in different ways.

但我认为确实相当一部分教职工,虽然有不同的理解，但能做到尽职尽责。

普林斯顿公开课 - 人性课程节选

And so this is a substantial change in the interaction of a microorganism with a population, right?

所以这是微生物和人类,之间关系的一个巨大改变,对吧

耶鲁公开课 - 生物医学工程探索课程节选

Someone might also say, you know a little inequality, even a substantial inequality, is not so bad as long as nobody is really suffering.

有些人也可能会说，微小的贫富差距，甚至显著的贫富差距存在，只要没人觉得痛苦就行了。

耶鲁公开课 - 金融市场课程节选

Typically, we are oblivious to these factors that change our points and this is, in fact, a substantial and an important part of the study of psychology, and particularly, for instance, the study of racial and sexual prejudice.

通常，我们觉察不到,这些能够改变我们看法的因素,无意识实际上，是心理学研究中的一个重要内容，特别是在对种族偏见和性别偏见的研究中，会表现的更加明显。

耶鲁公开课 - 心理学导论课程节选

So, over the course of time this could have a very substantial impact on the community.

所以,这种病毒在一段时间内,会对当地社会产生持续的影响

耶鲁公开课 - 生物医学工程探索课程节选