You make not small changes in their chemistry but big changes in their chemistry.

它们的化学性质,就会发生巨大的改变

耶鲁公开课 - 生物医学工程探索课程节选

That - irreversible changes happen all the time too but here I'm talking about very subtle small changes where you're changing the structure of the protein but only a little bit such that it can go back.

这种不可逆的改变时时刻刻都在发生,但我在这里想讲的是,对蛋白质结构进行微小的改变,小到这种改变是可逆的

耶鲁公开课 - 生物医学工程探索课程节选

It takes place in small rooms. If you begin to think about it, you can almost see the set changes: in the diner, on the train station. That's about the most open place, on the train platform. That's about the most open place we see.

在很小的空间里发生，如果你们开始思考它，你们几乎能看到场景的改变，晚饭，在火车站，那算是最室外了，在火车的月台上，那也算是最室外了。

耶鲁公开课 - 1945年后的美国小说课程节选