One thing I do want you to remember is that IgM class antibodies are the antibodies produced on first exposure.

我希望你们记住的一点是,IgM类抗体是人体在,第一次接触抗原时产生

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Most of them are of the class IgM; IgM antibodies are produced on first exposure.

其中大部分抗体都属于IgM,IgM在机体首次接触抗原时产生的

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Why do you think IgM are produced on first exposure?

为什么IgM是在初次免疫期间产生

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If you looked at the antibodies that were present in the blood, for example, you would find that most of those antibodies are IgM during this initial period of antibody concentration rise.

如果你现在观察血液中存在的抗体,举个例子,在初次免疫的抗体浓度上升阶段,你将会发现大部分的抗体都是IgM

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Well, one way to think about is they have more antigen binding sites and so they're going to be more efficient at neutralizing the pathogen on a per-molecule basis than IgG is.

可以这么考虑,因为IgM表面有更多的抗原结合位点,所以相对于IgG,IgM在分子层面上,能够更为有效地与病原体结合

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The IgM is really five IgG-type molecules that are linked together through disulfide bonds, such that their FC portions are all pointing in and their antibody binding portions are all pointing out.

gM是由五个IgG分子组成的,IgG分子之间通过二硫键连接,免疫球蛋白尾部的FC片段都指向内侧,而抗体的抗原结合位点都指向外侧

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The memory cells, which are stimulated, lead to an IgG response and that's why IgG is the antibody of-- that is produced predominantly after the boost, but there is some IgM produced also.

记忆细胞受到刺激之后,可以诱发分泌IgG的应答反应,这也是为什么IgG,是接种疫苗后产生的主要抗体,与此同时也刺激产生了一些IgM

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If you looked later, as the antibody production response matures, some IgG is produced so that in the late period after initial priming you'd have a mixture of IgM and IgG in the blood.

如果你稍后再观察,等到产生抗体的应答趋于成熟后,就会产生一些IgG抗体,在初次免疫的最终阶段,你的血液中有IgM,和IgG两种抗体

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Another important class of antibodies is called IgM.

另一种重要的抗体是免疫球蛋白M

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