Because nutrition is going to be one of the big problems of your generation; how to have enough nutritious food for the population as it grows.

因为营养,对你们这一代人是个大问题,怎样才能确保食物的质和量,能够满足日益增长人口的需求

耶鲁公开课 - 生物医学工程探索课程节选

And sometimes what we do, what we want to do is have them solve problems before problems get to be too big.

所以我们做的这些，就是为了在问题发生之前就解决了。

驯服淘气的人 - SpeakingMax英语口语达人

But other companies get heavily indebted and then they can go through big problems.

但其他公司则有着高负债,以便度过难关

耶鲁公开课 - 金融市场课程节选

They appear in food in pretty small amounts which is why they're the micronutrients;, but they're vital for health, so if you're deficient in micronutrients you've got big problems.

它们在食物中所占比重很小,这也是称它们为"微量元素"的原因,但它们对健康的意义却是至关重要的,如果缺乏微量元素的话会很糟糕

耶鲁公开课 - 关于食物的心理学、生物学和政治学课程节选

One of the big problems with studying human diseases is that you can study how they occur in people but there's only a limited amount that you can learn from people.

在人类疾病研究中的一个难题是,你有能力研究发病原因,但以人类为样本做研究却是备受限制

耶鲁公开课 - 生物医学工程探索课程节选

What he suggested is "Manhattan-Project-type attacks upon what I consider to be the truly Big Problems of our time, not only for psychology but for all human beings " with any sense of historical urgency".

他表明“曼哈顿计划“反驳了,当时最大的问题，这不仅是对心理学，甚至对所有人类都,带来了历史紧迫感。

哈佛公开课 - 幸福课课程节选

And what's striking about these is--it's not-- these are not just sort of big, screwy problems of messed up people.

而更加惊人的是,这些并不是只疯子们,才会拥有的严重且古怪的心理问题

耶鲁公开课 - 心理学导论课程节选

Local people would attack the Jews, or the Jews would try to set up an extra big meeting house for themselves, and it would cause local problems.

当地人攻击犹太人，或者犹太人企图建造超大的礼拜堂，引起各种问题。

耶鲁公开课 - 新约课程节选