It's very water soluble and it's a big molecule, a very big molecule; it can't naturally get inside cells on its own.

它是一个水溶性极强的大分子,非常非常大的分子,质粒在自然状态下并不能自己进入细胞

耶鲁公开课 - 生物医学工程探索课程节选

The Russian empire, the state of Muscovy had already expanded greatly, but it's really Peter the Great, it's the big guy who expanded Russia, its territorial size enormously.

沙俄帝国在此之前已有大幅扩张,但是,是彼得大帝,是这个大家伙扩张了俄国领土,他统治下的沙俄幅员辽阔

耶鲁公开课 - 欧洲文明课程节选