It's a bit more-- to continue with the metaphor of the on-of switch-- as though not only is the switch turned to off, there's a lock on the switch.

要继续用开关的比喻-,就有点奇怪了-,似乎开关的上面，还有一个锁定装置。

耶鲁公开课 - 死亡课程节选

It's taking me a while to lock on to that tonic.

锁定主音花了我一点时间。

耶鲁公开课 - 聆听音乐课程节选

These junctions, these red dots here are actually made up of proteins, some are synthesized by one cell, some are synthesized by each other, and they lock together to form a very tight barrier, to form a tight junction between the two cells.

这些红点表示细胞连接,实际上是由蛋白质构成的,有些是由一个细胞单独生成的,有些是由两个细胞共同生成,使这两个细胞紧锁在一起形成紧密的屏障,并在两细胞间形成紧密连接

耶鲁公开课 - 生物医学工程探索课程节选