That disease was brought to them by the Spanish when they came to these continents in the 16th Century.

西班牙人在十六世纪,来到这个大陆时带来了这种疾病

耶鲁公开课 - 生物医学工程探索课程节选

And the reason I was was that I was interested in how the modern world came into being and it came into being I think in the late 16th century in some sense.

这是因为我对,现代世界的形成很感兴趣，而我认为,从某种意义上它是在十七世纪末期形成的。

普林斯顿公开课 - 人性课程节选

Muscovy had already conquered the Volga basin in the 16th century, where the nomadic Tatars were, T-A-T-A-R-S.

6世纪时莫斯科公国已经征服了伏尔加盆地,游牧鞑靼民族住的地方

耶鲁公开课 - 欧洲文明课程节选