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In other words, for an electron donor to give up its electron, the electron donor needs to have an electron acceptor.
换句话说，如果一个电子给体要失去电子，它就必须找到一个电子受体。
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There's not actually chemical covalent bonds that are formed but it's a non-covalent interaction, usually dominated by hydrogen bonding.
所以配体和受体之间不生成共价键,这是一种非共价化合反应,它们通常以氢键相联
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So, these are poor electron donors but also a good electron acceptors, and we call these non-metals.
所以这些元素都不易失电子,但是它们是很好的电子受体，我们把这些叫做非金属。
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What are - this understanding of receptor-ligand interactions has been really the biological basis of much of the pharmaceutical industry.
受体-配体相互作用理论,现在已经成为很多,制药工业的生物学基础
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Most cells in your body have insulin receptors so insulin is starting to bind to insulin receptors on those cells.
体内大多数细胞中都有胰岛素受体,胰岛素就开始与细胞上的胰岛素受体结合
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It might be getting a signal from this receptor and a signal from this receptor, and a signal from this receptor.
细胞可能同时从这个受体,这个受体,以及这个受体接收信号
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I mentioned earlier, we thought about receptors as being these blocks and membranes but there are different families of receptors.
我之前讲过,我们把受体看做一类,固定在细胞膜上的分子,但受体有许多不同家族
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They prevent the ligand from reaching its natural receptor, and so that antagonizes or inhibits the function of the natural ligand.
它们能够阻止配体与受体的结合,这样就拮抗或者说是抑制了配体的功能
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Sometimes receptors, when they interact with ligands, create changes in what proteins are actually being produced by the cell.
有时受体与配体结合后,带来的变化实际是,决定细胞开始合成何种蛋白质
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They go across the membrane - this is the trans-membrane part of the receptor that's going across the membrane.
它们跨越式的存在于细胞膜上,这就是受体的跨膜部分,它跨越了细胞膜
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It has to have an origin of replication, which we talked about last time, which is compatible with the cells.
所以质粒必须带有复制起点,我们上次讲过,该起点要与受体细胞匹配
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Many steroid hormones act because they bind to cellulars - to receptors that are deep within the cell, often inside the nucleus.
许多类固醇激素能够起效是因为,其与存在于细胞内部的受体相结合,这类受体通常在细胞核内
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What insulin is doing inside your body is acting as a ligand for insulin receptors which stimulate certain kinds of cellular responses.
胰岛素在体内的功能就是作为,胰岛素受体的配体,刺激产生某种细胞效应
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The cell is going to experience something different inside because both receptors were activated instead of just one.
细胞内部将经历不同的生理过程,因为是两种受体被激活而不是一种
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When estrogen is present it can enter cells in the vicinity and it can bind to receptors that are deep inside cells.
雌激素能够进入到邻近的细胞中,并能够与细胞内部的受体相结合
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These are molecules that exist naturally in cell membranes and are activated by certain enzymes and kinases generated by receptors.
这些分子存在于细胞膜表面,能被受体激活的某种酶或激酶所活化
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But in general, for each neurotransmitter that released it there would only be one population of receptors that's ready to receive it.
但总体说,每一种在此释放的神经递质,只能被一类受体接受
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An example of a drug that works like that is the anti-cancer drug Tamoxifen which binds to estrogen receptors and blocks estrogen signaling.
这种药物的一个例子就是他莫昔芬,这是一种抗癌药,能够与雌激素受体结合,阻断雌激素信号通路
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We're going to take these general topics and talk about how they work in the nervous system and the immune system next time.
在下节课我会讲这些内容以及,配体-受体系统在神经系统和,免疫系统中的作用原理
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In the case of a ligand-receptor, a chemical signal in the form of a concentration of ligand gets converted into a biochemical signal.
在配体-受体系统中,配体浓度这种化学信号,转化为生化信号
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The same problem is with organ transplantation is that the recipient has to be matched to the donor and so that's a problem.
和器官移植中的问题一样,受体需要与供体匹配,这就是问题所在
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They bind sometimes better than the natural ligand does, but they don't create the right biological reaction.
结合的比天然配体和受体的的结合更紧密,但不能产生相同的生物效应
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When they bind, they produce some change in the receptor molecule which is experienced inside the cell.
当它们结合后,会使受体分子发生改变,这个过程发生在细胞内部
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So, it interacts with receptors called insulin receptors that are on cells that are sensitive to insulin.
它与细胞表面胰岛素受体相互作用,这些细胞对胰岛素很敏感
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What I want to do in here is just introduce some of the basic kinds of receptors.
我在这里想向你们介绍,几类基本的受体
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That's a big problem and so can you protect these cells that you give to the recipient from attack by the recipient's immune system?
并且至关重要,那么你们想办法保护这些植入受体的细胞,使它们免受免疫系统的排异反应么
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The rest of these examples refer to receptors as I've been describing them and ligands that are soluble and can move around the body.
我接下来要讲的有关受体,以及能游走于体内各处可溶性的配体
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Those receptors, some fraction of them, are specific for the ligand that the pre-synaptic cell releases.
这些受体 其中一部分,特异性地结合突触前细胞释放的配体
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This is - there are also other receptors that are linked to other enzymes besides kinases.
除了激酶以外,还有很多其他的受体,与酶相偶联
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We've identified many drugs that stimulate insulin receptors, for example, but they're not exactly insulin, and those can potentially be used as agonist type drugs.
我们已经设计了很多,能够激活胰岛素受体的药物,但它们都不是和胰岛素分毫不差的,但都可以用作激动剂类药物
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