This is a big change from earlier models where NASA led and controlled the development of space vehicles.

VOA: special.2010.04.28

Sometimes that subtle change can lead to a big change in the function of the protein.

有时候,蛋白质在结构上的小小改变,会导致其功能发生巨大变化

耶鲁公开课 - 生物医学工程探索课程节选

and go back to change the laundry over and pick it up, and it's really a big pain. It's really awful.

然后走回去把衣服拿出来，真是太痛苦了，真的很烦人。

与众不同的纽约 - SpeakingMax英语口语达人

"It's a big deal. How big a deal you have to measure piece by piece but clearly it is the first major change in our health care system since nineteen sixty-five so that's a long time coming."

VOA: special.2010.03.27

The only big change came in 1960 when they consolidated the ones around Paris, because of the growth of the Paris region, as you can see there.

仅在1960年由于巴黎区的发展,发生了一次改变,他们将巴黎周边的省进行合并,在这里可以看到

耶鲁公开课 - 1871年后的法国课程节选

President Obama said Senate Democrats now have the 60 votes they need to force big U.S.financial firms to change the way they do business.

VOA: standard.2010.07.13

The financial situation is not as bad as it was in the 1930s but it's getting bad and as a result we're starting to see proposals for big change.

现在的金融衍生工具已经不像当年那么拙劣了,但是它却开始走下坡路,所以最后的结果是,我们不得不准备着新的变革。

耶鲁公开课 - 金融市场课程节选

In the big cities, the traditional affinity to the precious metal is waning, as trends change.

VOA: standard.2009.09.19

Deforestation is one of the big culprits in climate change.

VOA: standard.2010.06.17