They homed in on a single gene, known as GNPTAB, which was defective in 46 members of a large Pakistani family.

VOA: standard.2010.02.11

It's a single gene defect and we know exactly where the genetic defect is in sickle cell.

是一种单基因缺陷,而且我们准确地知道,镰状红细胞贫血的基因缺陷在哪里

耶鲁公开课 - 生物医学工程探索课程节选

Usually this is a disease that's caused by a defect in a single gene.

通常在疾病是由,单基因缺陷引起时才可行

耶鲁公开课 - 生物医学工程探索课程节选

Because of this, because cystic fibrosis is a disease that's caused by a single gene defect, there's been great interest in trying to treat cystic fibrosis with gene therapy.

就是因为如此,就因为囊胞性纤维症,是一种单基因病,人们对于用基因治疗,治愈囊胞性纤维症产生了很大的兴趣

耶鲁公开课 - 生物医学工程探索课程节选

When it's double stranded this gene can't be translated, because you have to have the single strand in order for the transfer RNA to bind and for this process of translation to take place.

当基因处于双链结构状态时,是不能进行翻译的,因为必须把双链拆开得到单链,才能结合转运RNA并开始翻译过程

耶鲁公开课 - 生物医学工程探索课程节选