Here's the difference between normal hemoglobin and sickle hemoglobin, I can make - I can see a chemical difference, I can exploit it, how can I find it?

正常血红蛋白和镰状红细胞贫血的,血红蛋白有不同之处,我能够--我能看出有化学差异,我能去探寻差异,那么我怎么找到它呢

耶鲁公开课 - 生物医学工程探索课程节选

It's on the gene for hemoglobin and the hemoglobin that you produce if you have sickle cell anemia is not quite right because there's one base difference.

这个缺陷基因和血红蛋白有关,如果你有镰状红细胞贫血症,那你所产生的血红蛋白就不太正常,因为这里有一个碱基不同

耶鲁公开课 - 生物医学工程探索课程节选

In a normal cell DNA that DNA in the normal cell - this DNA gets cut by the restriction enzyme, so the sickle gene ends up - so that hemoglobin gene ends up in two pieces.

一个正常细胞的DNA,正常细胞里的DNA,会被限制酶所剪切,因此镰状血红蛋白基因--,不对,是正常血红蛋白基因被切成两段

耶鲁公开课 - 生物医学工程探索课程节选