Sometimes that subtle change can lead to a big change in the function of the protein.

有时候,蛋白质在结构上的小小改变,会导致其功能发生巨大变化

耶鲁公开课 - 生物医学工程探索课程节选

You know that the function of a protein is intimately related to its structure.

蛋白质的功能与结构密切相关

耶鲁公开课 - 生物医学工程探索课程节选

I couldn't have told you, for example, if we look at a phosphate group, that that's going to be incredibly important in DNA, that it's also an incredibly important group when you're dealing with proteins and whether you're turning the function of a protein on or off.

怎么和化学反应相联系起来的，更不记得其它我更不感兴趣的规律,我不能告诉你，如果我们看磷酸盐,它们对于构成DNA十分重要,也是构成蛋白质的重要组份,它是否能打开或关闭一个蛋白质的功能。

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You're able to make the protein but the protein doesn't function properly.

肺上皮细胞可以表达这种蛋白,但其并不具有正常功能

耶鲁公开课 - 生物医学工程探索课程节选

Reverse transcriptase is a naturally occurring protein, it has a biological function in HIV, but we can use it for a technical logical function here by going backwards on the biological path from messenger RNA to DNA.

反转录酶是在自然环境中存在的蛋白质,它在HIV中发挥着生物功能,但在这里它可以发挥一个技术功能,让它用信使RNA反转录出DNA

耶鲁公开课 - 生物医学工程探索课程节选