The Georgian issue is a major point of disagreement between the United States and Russia.

VOA: standard.2010.07.05

The Delphic story for what it's worth marks a major turning point in Socrates' intellectual biography.

德尔菲神谕事件，不论好坏,都标志着,一个苏格拉底思想传记中的重要转折点。

耶鲁公开课 - 政治哲学导论课程节选

So, at this point, kept the pre-med, just switched the major to chemistry.

如果你一心一意的要学生物学，我猜你会选择有机化学。

麻省理工公开课 - 化学原理课程节选

The affects of climate change have been a major point of discussion for international firefighting experts gathered in Sydney to look at ways to fight bushfires.

VOA: standard.2009.06.24

A major point of difference between the two main parties is whether the government should offer a health insurance program to compete with private insurance companies in an effort to drive down health care costs.

VOA: standard.2009.09.04

Dubai,Radia points out, is a major transit point for foreign travelers and an upscale shopping destination in the Middle East.

VOA: standard.2010.08.02

Major world powers disagree and are expected to drive that point home with the threat of further sanctions in talks with Iranian nuclear representatives in Geneva Thursday.

VOA: standard.2009.09.28