It is a very old expression. Hot water was used five hundred years ago to mean being in trouble.

VOA: special.2009.05.10

When our political opponent is being ironic about our views we understand the irony perfectly well. We're used to it, we have accommodated ourselves to it, and of course it's the same in reverse.

当政敌讽刺我们的观点,我们能够充分的理解这个讽刺，我们已经习惯这点了,是我们使自己习惯这点的，当然，反之亦然。

耶鲁公开课 - 文学理论导论课程节选

You get the idea here, is to deliver the gene that you're interested in directly to the tissue where it's being used and in this case, the idea is to introduce a gene that's missing.

但首先你要明确,这种思路是用来将,某个目的基因直接导入,它原本就能被利用的组织中的,此例中是导入一种缺失的基因

耶鲁公开课 - 生物医学工程探索课程节选

Another approach which is still investigational, in that it's being tried for many diseases but not yet clinically used in any particular one, is maybe you don't need to introduce a whole virus or pieces of a protein at all.

另一种方法目前仍处于试验阶段,该方法即将试用于许多疾病,但还没有对某一特定疾病进行临床试验,那就是无需引入整个病毒,或者根本不用引入蛋白质片段

耶鲁公开课 - 生物医学工程探索课程节选