So we are going to be fighting a huge number of technology challenges. Then there is the whole scale issue.

VOA: standard.2009.09.24

Cell proliferation is a huge issue in cell culture.

细胞增殖是细胞培养中的重大课题

耶鲁公开课 - 生物医学工程探索课程节选

Now, the reason this condition always holds in ordinary mechanics is because you're never, in that case, concerned with a huge statistical population of particles where the disorder among them is an issue.

这个条件在力学中总是成立,这是因为在力学中,我们从来没有关注过大量粒子的统计行为，而对这些系统来说,无序是很重要的。

麻省理工公开课 - 热力学与动力学课程节选

You-- It's been a series of-- a huge controversy in the popular culture to the extent of which parents matter and this is an issue which will preoccupy us for much of the course.

你,有一系列的,关于父母在多大程度上起作用,在流行文化里是有很大争议的,我们将会在这门课里用很多的时间,来讲这个问题

耶鲁公开课 - 心理学导论课程节选