I want to start by showing you this cartoon that you already know about with the structure of a double helix.

我想要给你们看这张卡通模型,你们都知道,这是DNA双螺旋结构

耶鲁公开课 - 生物医学工程探索课程节选

They will reform their natural structure, and for DNA that means forming double helixes.

它们将重新形成原本的结构,对于DNA来说,就是重新形成DNA双螺旋

耶鲁公开课 - 生物医学工程探索课程节选

If I took two double stranded DNA molecules and I exposed them to certain conditions that caused them to denature, that means its native structure falls apart.

假如我把两条DNA双链,放在特定的条件下,使它们变性,变性表示使它们的原始结构分开

耶鲁公开课 - 生物医学工程探索课程节选

DNA is a double helix, you know this, the double helix was--the structure of DNA was discovered about the time that I was born you've always lived with it.

NA是双螺旋结构,众所周知,DNA的这种双螺旋结构,是在我出生的那个年代才被发现的,它就是你生命的一部分

耶鲁公开课 - 生物医学工程探索课程节选

The native structure is this double stranded structure here and if I heat it up slightly and I add some base, so under slightly basic conditions, these molecules will fall apart because you've created conditions where the hydrogen bonding is no longer favorable so they peel apart.

原始结构,在这里就是指DNA双链,如果我稍微加热,并且加入一些碱,在弱碱性的条件下,这些配对碱基会分开,这是因为在一定条件下,碱基对之间的氢键,不再稳定并且会断裂分开

耶鲁公开课 - 生物医学工程探索课程节选

Now DNA is a double helix and I've only shown you one part of the helix, right? I've shown you one upright strut and a base hanging off of it, but it forms a double helix because complementary strands of DNA strongly associate with one another and that's a very stable structure.

NA是双螺旋,我只是给你们讲了螺旋的一边,我给你们演示,一条链的支柱及碱基团,但其能构成双螺旋,是因为DNA是完全互补的两条链,彼此之间结合紧密,结构异常稳定

耶鲁公开课 - 生物医学工程探索课程节选