But Todd Duncan began a major change in classical musical performance in the United States.

VOA: special.2010.03.07

That didn't happen to me -- once I got into the lab, I didn't want to leave. So, I thought, "You know what, I think I'll change the medical school plans and now I'm going to go all the way -- chemistry major, chemistry grad school."

这很好，但我不是这样，我一进入到实验室就不想离开了，所以我想“你知道吗,我想把我学习医学的计划改成化学-,我要学化学专业，读化学研究生“

麻省理工公开课 - 化学原理课程节选

So, the banks said, of course we'll do that; that created a major change in mortgage lending.

所以银行说,我们当然愿意这样,这是抵押贷款的一个巨大的变革

耶鲁公开课 - 金融市场课程节选

"Liberating ourselves, we will then become a major political force, perhaps the biggest political force for basic social and political change in America in the seventies."

VOA: special.2009.10.18

Now the modulation--change of key from major to back to minor as the cortege will start up again and then we-- A nice clarinet sound there and here comes our cortege with the bass.

现在变调了,从大调,变回小调,送葬行列再次启动,然后我们听到了优美的单簧管,送葬行列伴随着低音来了

耶鲁公开课 - 聆听音乐课程节选

Hubble's discovery meant a major change in our idea of the universe.

VOA: special.2009.04.29

Well, with the first movement we said he's generally going and that kind of idea, but now it's and we'll explore this when we get to harmony, this idea of major and minor so we're going music and now and that's a change from the dark minor to the brighter major.

在第一乐章,我们说过它大体上,就像这样,但现在,我们讲到和弦时再来研究这个,大调和小调的概念,我们继续听音乐,还有这个,这就是小调到大调间的转变,由阴郁转向明亮

耶鲁公开课 - 聆听音乐课程节选

But one major change was beyond the museum's control.

VOA: special.2009.01.11

"It's a big deal. How big a deal you have to measure piece by piece but clearly it is the first major change in our health care system since nineteen sixty-five so that's a long time coming."

VOA: special.2010.03.27

Waskow says the major challenges created for many poor countries by climate change, calls for long-term investment.

VOA: standard.2009.12.11

Foreign Ministry spokeswoman Jiang Yu Tuesday said one of the major issues is money to help developing nations cope with the effects of climate change.

VOA: standard.2009.12.16

Senator McCain,who competed for the White House against then-candidate Obama last year, also harshly criticized the way the Obama administration announced this major policy change.

VOA: standard.2009.09.24

He says the new Obama war strategy, which also includes a major rehaul of civilian development projects, sounds like a hopeful change from the past.

VOA: standard.2009.06.15

The affects of climate change have been a major point of discussion for international firefighting experts gathered in Sydney to look at ways to fight bushfires.

VOA: standard.2009.06.24

She says climate change is a major priority in the Obama Administration.

VOA: standard.2009.08.31

One resolution was approved a declaration calling for concerted global action on climate change ahead of a major United Nations conference on the subject scheduled for December in Copenhagen.

VOA: standard.2009.10.17