Too much cortisol and adrenalin can result in physical problems and changes that lead to stress-related sickness.

VOA: special.2009.03.24

When left untreated,however, it can lead to changes in a person's physical appearance and even death.

VOA: special.2010.07.06

Now he would just like to walk again. TBI can lead to physical disabilities as well as changes in mental ability, personality and behavior.

VOA: standard.2010.05.25