The most serious occurred in 1918 when upwards of 50 million people are believed to have died.

VOA: standard.2009.05.14

World Health Organization Director-General Margaret Chan says when H1N1 appeared her agency was expecting an event similar to the 1918 pandemic, which killed 50 million people.

VOA: standard.2010.01.18

And scientists have done similar research on the 1918 Spanish flu epidemic.

VOA: standard.2010.05.05

Since 1918. That's when Carlisle found medying of Spanish influenza.

VOA: standard.other

This is welcome news for U.S.health officials, who initially had to consider the possibility that the new flu strain's impact could mirror the devastation of the 1918 influenza pandemic that led to tens of millions of deaths worldwide.

VOA: standard.2009.05.03